QSAR: hydropathic analysis of inhibitors of the p53-mdm2 interaction (Q30665587)

26 June 2017

QSAR: hydropathic analysis of inhibitors of the p53-mdm2 interaction (English)

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26 June 2017

P S Galatin

1

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PubMed ID

11599019

26 June 2017

D J Abraham

series ordinal

2

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PubMed ID

11599019

26 June 2017

language of work or name

English

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publication date

1 November 2001

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26 June 2017

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26 June 2017

45

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26 June 2017

3

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26 June 2017

169-175

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The MDM2 gene amplification database

26 June 2017

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Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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Repression of p53-mediated transcription by MDM2: a dual mechanism

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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A closer view of an oncoprotein-tumor suppressor interaction

21 January 2018

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

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The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

21 January 2018

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Hydrophobicity: is LogP(o/w) more than the sum of its parts?

21 January 2018

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Hydropathic analysis of the non-covalent interactions between molecular subunits of structurally characterized hemoglobins

21 January 2018

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Computational methodology for estimating changes in free energies of biomolecular association upon mutation. The importance of bound water in dimer-tetramer assembly for beta 37 mutant hemoglobins.

21 January 2018

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Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction analysis of novel hemoglobin oxygen effectors

21 January 2018

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Differences in hydropathic properties of ligand binding at four independent sites in wheat germ agglutinin-oligosaccharide crystal complexes

21 January 2018

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Identification and hydropathic characterization of structural features affecting sequence specificity for doxorubicin intercalation into DNA double-stranded polynucleotides

21 January 2018

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All-atom models for the non-nucleoside binding site of HIV-1 reverse transcriptase complexed with inhibitors: a 3D QSAR approach

21 January 2018

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HINT: a new method of empirical hydrophobic field calculation for CoMFA.

21 January 2018

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Three-dimensional quantitative structure-activity relationship study on cyclic urea derivatives as HIV-1 protease inhibitors: application of comparative molecular field analysis

21 January 2018

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Evaluating docked complexes with the HINT exponential function and empirical atomic hydrophobicities.

21 January 2018

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Use of 3D QSAR methodology for data mining the National Cancer Institute Repository of Small Molecules: application to HIV-1 reverse transcriptase inhibition

21 January 2018

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Molecular characterization of the hdm2-p53 interaction

21 January 2018

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21 January 2018

The Protein Data Bank

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p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate

21 January 2018

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Low Grade Amplification of MDM2 Gene in a Subset of Human Breast Cancers without p53 Alterations

21 January 2018

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Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53

21 January 2018

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Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations

21 January 2018

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Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: a comparative molecular field analysis study

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PROT.1136

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26 June 2017

1 reference

PubMed ID

11599019