Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains (Q30769503)

26 June 2017

Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains (English)

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26 June 2017

Martin Fugère

1

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26 June 2017

Polizois C Limperis

2

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26 June 2017

Véronique Beaulieu-Audy

3

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26 June 2017

Frédéric Gagnon

4

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26 June 2017

Pierre Lavigne

5

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26 June 2017

Klaus Klarskov

6

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26 June 2017

Richard Leduc

7

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26 June 2017

Robert Day

8

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26 June 2017

language of work or name

English

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publication date

26 November 2001

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Journal of Biological Chemistry

26 June 2017

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26 June 2017

277

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26 June 2017

10

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26 June 2017

7648-7656

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Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications

26 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Conservation of the prohormone convertase gene family in metazoa: analysis of cDNAs encoding a PC3-like protein from hydra

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M107467200

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

A model for the structure of the P domains in the subtilisin-like prohormone convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Regulatory roles of the P domain of the subtilisin-like prohormone convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Region specific expression of furin mRNA in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Proteolytic cleavages of proalbumin and complement Pro-C3 in vitro by a truncated soluble form of furin, a mammalian homologue of the yeast Kex2 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

A protein-based therapeutic for human cytomegalovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Comparative characterization of two forms of recombinant human SPC1 secreted from Schneider 2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

17 The kinetics of reversible tight-binding inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Polyarginines are potent furin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Stability and global fold of the mouse prohormone convertase 1 pro-domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Folding pathway mediated by an intramolecular chaperone

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M107467200

Secretion and autoproteolytic maturation of subtilisin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Catalysis of a protein folding reaction: mechanistic implications of the 2.0 A structure of the subtilisin-prodomain complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

A Robust, Detergent-Friendly Method for Mass Spectrometric Analysis of Integral Membrane Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Furin and membrane type-1 metalloproteinase mRNA levels and activation of metalloproteinase-2 are associated with arterial remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Processing and sorting of the prohormone convertase 2 propeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Rapid folding of calcium-free subtilisin by a stabilized pro-domain mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

Convertases other than furin cleave beta-secretase to its mature form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107467200

21 January 2018

Identifiers

DOI

10.1074/JBC.M107467200

1 reference

26 June 2017

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