Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited (Q30824534)

26 June 2017

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title

Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited (English)

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26 June 2017

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Alberto Chiarugi

1

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26 June 2017

publication date

1 March 2002

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Trends in Pharmacological Sciences

26 June 2017

published in

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26 June 2017

volume

23

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26 June 2017

issue

3

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26 June 2017

page(s)

122-129

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Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death

26 June 2017

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7 January 2021

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

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7 January 2021

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion

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7 January 2021

Poly (ADP-ribose) polymerase, nitric oxide and cell death

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7 January 2021

The world according to PARP.

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7 January 2021

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.

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7 January 2021

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

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7 January 2021

Role of poly(ADP-ribose)synthetase in inflammation

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7 January 2021

Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice

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7 January 2021

Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase

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7 January 2021

Poly(ADP-ribose) polymerase-1 in the nervous system

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7 January 2021

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

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7 January 2021

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers

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7 January 2021

NAD(+) consumption in carcinogen-treated hamster cells overexpressing a dominant negative mutant of poly(ADP-ribose) polymerase

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7 January 2021

Mechanisms of endothelial cell ATP depletion after oxidant injury

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7 January 2021

ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose).

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7 January 2021

Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation

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7 January 2021

Effect of transient focal ischemia of mouse brain on energy state and NAD levels: no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism

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7 January 2021

Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks.

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7 January 2021

PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

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7 January 2021

A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues

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7 January 2021

Tankyrase promotes telomere elongation in human cells

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7 January 2021

Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles

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7 January 2021

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14

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7 January 2021

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

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7 January 2021

The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase

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7 January 2021

Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission

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7 January 2021

A fast signal-induced activation of Poly(ADP-ribose) polymerase: a novel downstream target of phospholipase c.

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7 January 2021

Phosphorylation of poly(ADP-ribose)polymerase protein in human peripheral lymphocytes stimulated with phytohemagglutinin

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7 January 2021

A cellular survival switch: poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription

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7 January 2021

A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage

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7 January 2021

Association of poly(adenosine diphosphate ribosylated) nucleosomes with transcriptionally active and inactive regions of chromatin

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7 January 2021

Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro

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7 January 2021

Involvement of poly (ADP-ribose)-polymerase in the Pax-6 gene regulation in neuroretina.

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7 January 2021

PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.

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7 January 2021

Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase

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7 January 2021

A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation

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7 January 2021

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

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7 January 2021

A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression

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7 January 2021

Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration

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7 January 2021

Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription

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7 January 2021

Multiprotein complex formation at the beta myosin heavy chain distal muscle CAT element correlates with slow muscle expression but not mechanical overload responsiveness

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7 January 2021

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

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7 January 2021

How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

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7 January 2021

The Rel/NF-kappa B family: friend and foe.

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7 January 2021

Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation

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7 January 2021

Poly (ADP-ribose) polymerase is involved in PMA-induced activation of HIV-1 in U1 cells by modulating the LTR function.

1 reference

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7 January 2021

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

1 reference

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7 January 2021

Chromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Role of NF-κB in p53-mediated programmed cell death

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

Transcriptional cross talk between NF-kappaB and p53.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7

7 January 2021

10.1016/S0165-6147(00)01902-7

Identifiers

DOI

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26 June 2017

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