Heterodimerization of gamma-aminobutyric acid B receptor subunits as revealed by the yeast two-hybrid system. (Q30846602)

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12 November 2019

title

Heterodimerization of gamma-aminobutyric acid B receptor subunits as revealed by the yeast two-hybrid system (English)

1 reference

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protein heterodimerization activity

12 November 2019

main subject

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3

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12 November 2019

author name string

Julia H White

series ordinal

1

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12 November 2019

Alan Wise

series ordinal

2

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12 November 2019

publication date

1 August 2002

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12 November 2019

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12 November 2019

volume

27

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issue

4

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12 November 2019

page(s)

301-310

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Oligomerization of G-protein-coupled transmitter receptors.

12 November 2019

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Heterodimerization is required for the formation of a functional GABA(B) receptor

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Heterodimerization of a functional GABAB receptor is mediated by parallel coiled-coil alpha-helices

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A trafficking checkpoint controls GABA(B) receptor heterodimerization

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Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor.

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GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

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GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

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C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

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The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling.

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Using the yeast interaction trap and other two-hybrid-based approaches to study protein-protein interactions

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The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx

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The metabotropic GABAB receptor directly interacts with the activating transcription factor 4

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Measurement of protein using bicinchoninic acid

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Measurement of receptor-stimulated guanosine 5'-O-(gamma-thio)triphosphate binding by G proteins

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Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

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Identifiers

DOI

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12 November 2019

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