Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. (Q30881593)

27 June 2017

title

Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. (English)

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27 June 2017

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8

Joseph V Bonventre

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27 June 2017

Lucia Cilenti

1

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27 June 2017

Younghee Lee

2

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27 June 2017

Sibylle Hess

3

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27 June 2017

Srinivasa Srinivasula

4

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27 June 2017

Kwon Moo Park

5

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27 June 2017

Daniela Junqueira

6

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27 June 2017

Hedvika Davis

7

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27 June 2017

Emad S Alnemri

9

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27 June 2017

Antonis S Zervos

10

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27 June 2017

language of work or name

English

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publication date

15 January 2003

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Journal of Biological Chemistry

27 June 2017

published in

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volume

278

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issue

13

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27 June 2017

page(s)

11489-11494

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Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia

27 June 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M212819200

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

21 January 2018

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The HtrA family of serine proteases

21 January 2018

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A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

21 January 2018

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Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212819200

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212819200

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212819200

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212819200

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212819200

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

21 January 2018

1 reference

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

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grim, a novel cell death gene in Drosophila

21 January 2018

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Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).

21 January 2018

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Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM.

21 January 2018

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sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein

21 January 2018

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

21 January 2018

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Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

21 January 2018

1 reference

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Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage

21 January 2018

1 reference

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Caspase-independent programmed cell death with necrotic morphology

21 January 2018

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An alternative, nonapoptotic form of programmed cell death

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M212819200

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27 June 2017

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