A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C. (Q30943394)

20 August 2017

A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C. (English)

1 reference

20 August 2017

Ajoy Basak

1

1 reference

20 August 2017

Abdel-Majid Khatib

2

1 reference

20 August 2017

Dayani Mohottalage

3

1 reference

20 August 2017

Sarmistha Basak

4

1 reference

20 August 2017

Maria Kolajova

5

1 reference

20 August 2017

Subhendu Sekhar Bag

6

1 reference

20 August 2017

Amit Basak

7

1 reference

20 August 2017

language of work or name

English

0 references

publication date

26 November 2009

1 reference

20 August 2017

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20 August 2017

4

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20 August 2017

11

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20 August 2017

e7700

1 reference

Creative Commons Attribution 4.0 International

20 August 2017

start time

26 November 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site

14 July 2018

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Processing of peptide and hormone precursors at the dibasic cleavage sites

14 July 2018

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A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness

14 July 2018

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The activation and physiological functions of the proprotein convertases

14 July 2018

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Protein secondary structure analyses from circular dichroism spectroscopy: methods and reference databases

14 July 2018

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Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens

14 July 2018

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Enediyne compounds - new promises in anticancer therapy

14 July 2018

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Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity

14 July 2018

1 reference

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Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine

14 July 2018

1 reference

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Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Inhibitors of proprotein convertases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Modulating furin activity with designed mini-PDX peptides: synthesis and in vitro kinetic evaluation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Interaction of EGLIN C variants with the extended subsites of the precursor processing proteases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Chelation-Controlled Bergman Cyclization: Synthesis and Reactivity of Enediynyl Ligands

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Furin at the cutting edge: from protein traffic to embryogenesis and disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Protein-degrading enediynes: library screening of Bergman cycloaromatization products

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

A protein-based therapeutic for human cytomegalovirus infection

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Selective proteolytic activity of the antitumor agent kedarcidin

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

14 July 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007700

Synthetic small-molecule prohormone convertase 2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007700

p-Benzyne. Generation as an intermediate in a thermal isomerization reaction and trapping evidence for the 1,4-benzenediyl structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007700

Benzene fused monocyclic enediynyl amides: synthesis, reactivity and DNA-cleavage activity in comparison to the corresponding sulfonamides

21 January 2018

1 reference

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Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007700

Design and synthesis of enediyne-peptide conjugates and their inhibiting activity against chymotrypsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007700

A fluorogenic peptide containing the processing site of human SARS corona virus S-protein: kinetic evaluation and NMR structure elucidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007700

Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007700

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007700

Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

Design of peptide inhibitors for furin based on the C-terminal fragment of histone H1.2.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778948

The potent inhibitory activity of histone H1.2 C-terminal fragments on furin

25 November 2018

1 reference

12 December 2020

Conformational analyses of a partially-folded bioactive prodomain of human furin

1 reference

12 December 2020

Enediynes and related structures in medicinal and biorganic chemistry

1 reference

12 December 2020

Synthesis of tight binding inhibitors and their action on the proprotein-processing enzyme furin

1 reference

12 December 2020

Peptidyl substrates containing unnatural amino acid at the P'1 position are potent inhibitors of prohormone convertases

1 reference

12 December 2020

Understanding enediyne-protein interactions: diyl atom transfer results in generation of aminoacyl radicals

1 reference

12 December 2020

Design and synthesis of a novel enediynyl pentapeptide with predominantly beta-turn structural motif and its potential as a fluorescence-based chemosensor

1 reference

12 December 2020

Proprotein convertases as therapeutic targets

1 reference

12 December 2020

Synthesis and protein degradation capacity of photoactivated enediynes

1 reference

12 December 2020

Photochemical and thermal bergman cyclization of a pyrimidine enediynol and enediynone

1 reference

12 December 2020

Maduropeptin: an antitumor chromoprotein with selective protease activity and DNA cleaving properties

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0007700

Identifiers

DOI

1 reference

20 August 2017

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20 August 2017

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