Small-molecule inhibitors of protein-protein interactions: progressing towards the dream (Q29617758)

Europe PubMed Central

title

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream (English)

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protein-protein interaction

30 April 2017

main subject

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Arkin MR

1

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30 April 2017

Wells JA

series ordinal

2

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30 April 2017

language of work or name

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30 April 2017

publication date

April 2004

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Nature Reviews Drug Discovery

30 April 2017

published in

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30 April 2017

volume

3

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issue

4

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30 April 2017

page(s)

301-17

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Antibodies as therapeutic agents: vive la renaissance!

30 April 2017

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Nonpeptidic alpha(v)beta(3) Integrin Antagonist Libraries: On-Bead Screening and Mass Spectrometric Identification without Tagging The authors acknowledge technical assistance from M. Urzinger, B. Cordes, M. Kranawetter, and A. Schröder. Financial s

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Luxury accommodations: the expanding role of structural plasticity in protein-protein interactions

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

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Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α

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Characterization of potential antagonists of human interleukin 5 demonstrates their cross-reactivity with receptors for interleukin 3 and granulocyte-macrophage colony-stimulating factor

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A review of interleukin-2 receptor antagonists in solid organ transplantation

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Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor

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NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component, and with low molecular weight compounds that inhibit the IL-2/IL-Ralpha interaction

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The solution structure of the F42A mutant of human interleukin 2

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Potent small-molecule binding to a dynamic hot spot on IL-2

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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CTLA-4 can function as a negative regulator of T cell activation

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Molecular interactions mediating T cell antigen recognition

21 January 2018

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The interaction properties of costimulatory molecules revisited.

21 January 2018

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CTLA-4: new insights into its biological function and use in tumor immunotherapy

21 January 2018

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Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation

21 January 2018

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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

21 January 2018

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Structure and dimerization of a soluble form of B7-1

21 January 2018

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Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1.

21 January 2018

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Antibodies to B7.1 define the GFCC'C" face of the N-terminal domain as critical for co-stimulatory interactions.

21 January 2018

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The chemical biology of apoptosis. Exploring protein-protein interactions and the life and death of cells with small molecules

21 January 2018

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Regulation of apoptosis by Bcl‐2 family proteins

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BCL-2 family members and the mitochondria in apoptosis

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The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

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BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

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Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A.

21 January 2018

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

21 January 2018

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

21 January 2018

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

21 January 2018

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Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

21 January 2018

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A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors

21 January 2018

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Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

21 January 2018

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Second-site NMR screening and linker design

21 January 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

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Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

21 January 2018

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Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

21 January 2018

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Three-dimensional structural interactions of insulin and its receptor

21 January 2018

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Therapeutic antagonists and conformational regulation of integrin function

21 January 2018

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Nerve growth factor: structure and function

21 January 2018

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Nitric oxide synthases: structure, function and inhibition

21 January 2018

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21 January 2018

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Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

21 January 2018

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

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T-cell integrins: more than just sticking points

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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

21 January 2018

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

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Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

21 January 2018

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Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

21 January 2018

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Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

21 January 2018

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Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other

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Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition

21 January 2018

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Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

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1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

21 January 2018

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Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead

21 January 2018

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Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides

21 January 2018

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Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide

21 January 2018

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Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists

21 January 2018

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NMR solution structure of the inserted domain of human leukocyte function associated antigen-1

21 January 2018

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Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin

21 January 2018

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The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

21 January 2018

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Characterization of the allosteric inhibition of a protein-protein interaction by mass spectrometry

21 January 2018

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Small molecule LFA-1 antagonists compete with an anti-LFA-1 monoclonal antibody for binding to the CD11a I domain: development of a flow-cytometry-based receptor occupancy assay.

21 January 2018

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N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship

21 January 2018

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Nitric oxide as a signaling molecule in the vascular system: an overview.

21 January 2018

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Deletion of exon 6 of the neuronal nitric oxide synthase gene in mice results in hypogonadism and infertility

21 January 2018

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Inducible nitric oxide synthase: what difference does it make?

21 January 2018

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Nitric oxide and the immune response

21 January 2018

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Blocking NO synthesis: how, where and why?

21 January 2018

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Inducible Nitric Oxide Synthase - Time for Reappraisal

21 January 2018

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Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

21 January 2018

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PPA250 [3-(2,4-difluorophenyl)-6-[2-[4-(1H-imidazol-1-ylmethyl) phenoxy]ethoxy]-2-phenylpyridine], a novel orally effective inhibitor of the dimerization of inducible nitric-oxide synthase, exhibits an anti-inflammatory effect in animal models of ch

21 January 2018

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Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors

21 January 2018

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Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury.

21 January 2018

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The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury.

21 January 2018

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Effects of selective inhibitors of nitric oxide synthase-2 dimerization on acute cardiac allograft rejection

21 January 2018

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Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

21 January 2018

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Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

21 January 2018

1 reference

Protein-protein interfaces: architectures and interactions in protein-protein interfaces and in protein cores. Their similarities and differences

21 January 2018

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Structural plasticity in a remodeled protein-protein interface

21 January 2018

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Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

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Site-directed ligand discovery

21 January 2018

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Molecular complexity and its impact on the probability of finding leads for drug discovery

21 January 2018

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Is there a difference between leads and drugs? A historical perspective

21 January 2018

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Applications of SHAPES screening in drug discovery.

21 January 2018

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The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

21 January 2018

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NMR-based screening in drug discovery

21 January 2018

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High-throughput nuclear magnetic resonance-based screening

21 January 2018

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Design of adenosine kinase inhibitors from the NMR-based screening of fragments

21 January 2018

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Discovering novel ligands for macromolecules using X-ray crystallographic screening

21 January 2018

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Structure-based screening of low-affinity compounds

21 January 2018

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Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering

21 January 2018

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In situ assembly of enzyme inhibitors using extended tethering

21 January 2018

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Modern analytical ultracentrifugation in protein science: a tutorial review

21 January 2018

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Sedimentation equilibrium analysis of mixed associations using numerical constraints to impose mass or signal conservation

21 January 2018

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A new data analysis method to determine binding constants of small molecules to proteins using equilibrium analytical ultracentrifugation with absorption optics

21 January 2018

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Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

21 January 2018

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The two-dimensional transferred nuclear Overhauser effect: theory and practice

21 January 2018

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Survey of the year 2000 commercial optical biosensor literature

21 January 2018

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Direct measurement of protein binding energetics by isothermal titration calorimetry

21 January 2018

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High-throughput crystallography for lead discovery in drug design.

21 January 2018

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Small molecule ligands define a binding site on the immune regulatory protein B7.1

21 January 2018

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Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

21 January 2018

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Inhibition of protein-protein association by small molecules: approaches and progress

21 January 2018

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Nonpeptidic αv β3 Integrin Antagonist Libraries: On-Bead Screening and Mass Spectrometric Identification without Tagging

31 March 2020

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The use of antibodies against the IL-2 receptor in transplantation

31 March 2020

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Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor

31 March 2020

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The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure

31 March 2020

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Nitric oxide synthases: structure, function and inhibition

31 March 2020

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Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion

31 March 2020

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Cellular activation of leukocyte function-associated antigen-1 and its affinity are regulated at the I domain allosteric site

31 March 2020

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Sodium dodecyl sulfate-stable complexes of echistatin and RGD-dependent integrins: a novel approach to study integrins

31 March 2020

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Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

31 March 2020

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Neurotrophin receptors: mediators of life and death

31 March 2020

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A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in nerve growth factor

31 March 2020

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NGF ligand alters NGF signaling via p75(NTR) and trkA

31 March 2020

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Cysteine Proteases and Their Inhibitors

31 March 2020

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Conservation of polar residues as hot spots at protein interfaces

31 March 2020

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Characterizing a drug's primary binding site on albumin

31 March 2020

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Fibrinogen receptor antagonists: design and clinical applications

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Biology of the interleukin-2 receptor

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

2 references

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

957854

1040452458

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957854

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15060526

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017