The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes (Q31021169)

8 November 2017

The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes (English)

1 reference

8 November 2017

2

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8 November 2017

Petra Gran

1

1 reference

8 November 2017

25 June 2011

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8 November 2017

1 reference

8 November 2017

11

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8 November 2017

10

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Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids

8 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

mVps34 is activated following high-resistance contractions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Essential amino acid and carbohydrate ingestion before resistance exercise does not enhance postexercise muscle protein synthesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Identification of LAT4, a novel amino acid transporter with system L activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Amino acids stimulate translation initiation and protein synthesis through an Akt-independent pathway in human skeletal muscle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

A cellular model system of differentiated human myotubes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Physiological hyperinsulinemia stimulates p70(S6k) phosphorylation in human skeletal muscle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Regulation by nutrient limitation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Amino acid availability regulates p70 S6 kinase and multiple translation factors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Bidirectional modulation of insulin action by amino acids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Regulation of system A amino acid transport in 3T3-L1 adipocytes by insulin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Regulatory and molecular aspects of mammalian amino acid transport

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Leucine activates system A amino acid transport in L6 rat skeletal muscle cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Insulin and exercise stimulate muscle alpha-aminoisobutyric acid transport by a Na+-K+-ATPase independent pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Leucine. A possible regulator of protein turnover in muscle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Identification of features in 5′ terminal fragments from reovirus mRNA which are important for ribosome binding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes

21 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6793-11-10

Leucine induces phosphorylation and activation of p70S6K in cortical neurons via the system L amino acid transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6793-11-10

The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6793-11-10

Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6793-11-10

Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6793-11-10

Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6793-11-10

Impact of SOCS3 overexpression on human skeletal muscle development in vitro.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Suction applied to a muscle biopsy maximizes sample size.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141572

Leucine, glutamine, and tyrosine reciprocally modulate the translation initiation factors eIF4F and eIF2B in perfused rat liver

25 November 2018

1 reference

12 December 2020

Amino Acids Regulate Hepatocyte Proliferation through Modulation of Cyclin D1 Expression

1 reference

12 December 2020

Action of insulin on transport of L-alanine into rat diaphragm in vitro. Evidence that the hormone affects only one neutral amino acid transport system

1 reference

12 December 2020

Induction of amino acid transport in primary cultures of adult rat liver parenchymal cells by insulin

1 reference

12 December 2020

Regulation of protein synthesis by insulin

1 reference

12 December 2020

Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

1 reference

12 December 2020

Identifiers

DOI

10.1186/1472-6793-11-10

1 reference

Dimensions Publication ID

8 November 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1472-6793-11-10

1 reference

8 November 2017

PubMed publication ID

21702994

1 reference