hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase (Q40392574)

20 September 2017

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase (English)

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20 September 2017

Maya P Byfield

1

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20 September 2017

James T Murray

series ordinal

2

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20 September 2017

Jonathan M Backer

series ordinal

3

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20 September 2017

language of work or name

English

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publication date

27 July 2005

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Journal of Biological Chemistry

20 September 2017

7

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based on heuristic

inferred from page(s)

published in

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20 September 2017

280

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20 September 2017

33076-33082

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20 September 2017

38

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Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

The AMP-activated protein kinase cascade--a unifying system for energy control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Tuberous sclerosis complex: from Drosophila to human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3'-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Human VPS34 is required for internal vesicle formation within multivesicular endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Inhibition of autophagy in mitotic animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Characterization of cell lines showing growth control isolated from both the wild type and a leucyl-tRNA synthetase mutant of chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

Role and regulation of starvation-induced autophagy in the Drosophila fat body

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

p70s6k function is essential for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507201200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507201200

1 reference

20 September 2017

1 reference