Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR. (Q31036633)

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English	Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.	scientific article

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scholarly article

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Europe PubMed Central

28 June 2017

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Europe PubMed Central

Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR. (English)

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Europe PubMed Central

28 June 2017

molecular geometry

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Lesa L. Aylward

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Lesa L Aylward

2

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author name string

Kevin T Connor

1

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Europe PubMed Central

28 June 2017

publication date

1 March 2006

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Europe PubMed Central

28 June 2017

Journal of Toxicology and Environmental Health Part B: Critical Reviews

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Europe PubMed Central

28 June 2017

9

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Europe PubMed Central

28 June 2017

2

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Europe PubMed Central

28 June 2017

147-171

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Europe PubMed Central

28 June 2017

AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TCDD and comparison with mouse palate in vivo and in culture

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

PCBs and dioxin-like compounds in plasma of adult Inuit living in Nunavik (Arctic Quebec).

1 reference

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21 January 2018

Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines

1 reference

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21 January 2018

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

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21 January 2018

Tissue specific expression of the rat Ah-receptor and ARNT mRNAs

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21 January 2018

Constitutive activation of the aromatic hydrocarbon receptor

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21 January 2018

Real-time polymerase chain reaction analysis of CYP1B1 gene expression in human liver.

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J and DBA/2J mice.

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Induction of cellular oxidative stress by aryl hydrocarbon receptor activation

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https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes evidence for catalytic activity and mRNA expression.

1 reference

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21 January 2018

Subchronic Exposure of [3H]- 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female B6C3F1 mice: relationship of steady-state levels to disposition and metabolism.

1 reference

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21 January 2018

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition

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21 January 2018

Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates

1 reference

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21 January 2018

Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity.

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Severe 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients

1 reference

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21 January 2018

Molecular basis of dioxin actions: evidence supporting chemoprotection

1 reference

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21 January 2018

Induction of P-450 in workers exposed to dioxin

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Polymorphisms in the human AH receptor

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Effects of SH-modifying reagents on the rat hepatic Ah receptor: inhibition of ligand binding and transformation, and disruption of the ligand-receptor complex.

1 reference

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21 January 2018

Metabolism of polychlorinated dibenzo-p-dioxins and related dioxin-like compounds

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Tissue disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in maternal and developing long-evans rats following subchronic exposure.

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Comparison of human mouse P1450 upstream regulatory sequences in liver- and nonliver-derived cell lines.

1 reference

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21 January 2018

Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits

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21 January 2018

The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

The Ah receptor and the mechanism of dioxin toxicity

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident

1 reference

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21 January 2018

Origins of individual variability in P4501A induction

1 reference

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21 January 2018

Quantitative analysis of the Ah receptor/cytochrome P450 CYP1B1/CYP1A1 signalling pathway.

1 reference

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21 January 2018

Molecular determinants of hormone mimicry: halogenated aromatic hydrocarbon environmental agents

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects

1 reference

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21 January 2018

Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Chlorinated dibenzo-p-dioxins and dibenzofurans and the human immune system. 1. Blood cell receptors in volunteers with moderately increased body burdens.

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Physicochemical differences in the AH receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains.

1 reference

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21 January 2018

A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor

1 reference

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21 January 2018

Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells

1 reference

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21 January 2018

The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties

1 reference

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21 January 2018

Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).

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21 January 2018

Molecular biology of the Ah receptor and its role in carcinogenesis

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21 January 2018

7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor

1 reference

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21 January 2018

Genomic structure of the human Ah receptor nuclear translocator gene (hARNT).

1 reference

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21 January 2018

Induction of CYP1A and glutathione S-transferase activities by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatocyte cultures.

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21 January 2018

A ligand for the aryl hydrocarbon receptor isolated from lung

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21 January 2018

Significant shortcomings of the U.S. Environmental Protection Agency's latest draft risk characterization for dioxin-like compounds

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https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences.

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https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Human health effects after exposure to 2,3,7,8-TCDD

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife

1 reference

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21 January 2018

The Ah receptor, cytochrome P450IA1 mRNA induction, and aryl hydrocarbon hydroxylase in a human lymphoblastoid cell line

1 reference

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21 January 2018

Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Infant exposure to polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls (PCDD/Fs, PCBs)--correlation between prenatal and postnatal exposure.

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https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line

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21 January 2018

Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line HepG2, the rat hepatoma cell line H4IIE, and rat primary hepatocytes: comparison of relative potencies

1 reference

https://api.crossref.org/works/10.1080%2F15287390500196487

21 January 2018

Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer

1 reference

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21 January 2018

The Pig as a Model for Studying AH Receptor and Other PAH-Binding Proteins In Man

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21 January 2018

Identifiers

10.1080/15287390500196487

1 reference

Europe PubMed Central

28 June 2017

1 reference

Europe PubMed Central

28 June 2017

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