Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection (Q31086167)

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23 December 2019

review article

1 reference

title

Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection (English)

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23 December 2019

5

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23 December 2019

6

Tamar Schlick

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23 December 2019

author name string

Ravi Radhakrishnan

1

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23 December 2019

Karunesh Arora

2

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23 December 2019

Yanli Wang

3

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23 December 2019

William A Beard

4

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23 December 2019

language of work or name

English

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publication date

1 December 2006

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23 December 2019

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23 December 2019

volume

45

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23 December 2019

issue

51

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23 December 2019

page(s)

15142-15156

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Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes

23 December 2019

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Structure and mechanism of DNA polymerase Beta.

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A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).

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28 July 2018

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Structural evidence for a two-metal-ion mechanism of group I intron splicing

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DNA polymerase fidelity: kinetics, structure, and checkpoints

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In silico evidence for DNA polymerase-beta's substrate-induced conformational change

28 July 2018

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Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta.

28 July 2018

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Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly

28 July 2018

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Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta's closing

28 July 2018

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Structures of mismatch replication errors observed in a DNA polymerase

28 July 2018

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Characterization of the active site of DNA polymerase β by molecular dynamics and quantum chemical calculation

28 July 2018

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Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate

28 July 2018

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Computer simulation of the chemical catalysis of DNA polymerases: discriminating between alternative nucleotide insertion mechanisms for T7 DNA polymerase

28 July 2018

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The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction

28 July 2018

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DNA damage and repair

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Ten years of tension: single-molecule DNA mechanics

28 July 2018

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Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.

28 July 2018

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A reexamination of the nucleotide incorporation fidelity of DNA polymerases

28 July 2018

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Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus

28 July 2018

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Active site tightness and substrate fit in DNA replication

28 July 2018

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Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se.

28 July 2018

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Solution structure of a viral DNA repair polymerase

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Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

28 July 2018

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28 July 2018

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28 July 2018

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Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

28 July 2018

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28 July 2018

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A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity

28 July 2018

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Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

28 July 2018

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Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69

28 July 2018

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28 July 2018

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DNA polymerase beta: pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity.

28 July 2018

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28 July 2018

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Structure-function analysis of the mammalian DNA polymerase beta active site: role of aspartic acid 256, arginine 254, and arginine 258 in nucleotidyl transfer

28 July 2018

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28 July 2018

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Conformational coupling in DNA polymerase fidelity

28 July 2018

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28 July 2018

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Site-directed mutagenesis of recombinant rat DNA polymerase beta: involvement of arginine-183 in primer recognition

28 July 2018

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Aspartic acid residues at positions 190 and 192 of rat DNA polymerase beta are involved in primer binding

28 July 2018

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Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom

28 July 2018

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Energy analysis of chemistry for correct insertion by DNA polymerase beta

28 July 2018

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Sequential side-chain residue motions transform the binary into the ternary state of DNA polymerase lambda

25 November 2018

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Conformational transition pathway of polymerase beta/DNA upon binding correct incoming substrate

25 November 2018

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Fidelity discrimination in DNA polymerase beta: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair

25 November 2018

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Motions of the fingers subdomain of klentaq1 are fast and not rate limiting: implications for the molecular basis of fidelity in DNA polymerases

25 November 2018

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Use of viscogens, dNTPalphaS, and rhodium(III) as probes in stopped-flow experiments to obtain new evidence for the mechanism of catalysis by DNA polymerase beta.

25 November 2018

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Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations

25 November 2018

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A closed conformation for the Pol lambda catalytic cycle.

25 November 2018

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Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.

25 November 2018

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High-energy intermediate or stable transition state analogue: theoretical perspective of the active site and mechanism of beta-phosphoglucomutase

25 November 2018

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Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.

25 November 2018

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Mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase IV.

25 November 2018

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Rapid segmental and subdomain motions of DNA polymerase beta.

25 November 2018

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Use of 2-aminopurine and tryptophan fluorescence as probes in kinetic analyses of DNA polymerase beta

25 November 2018

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Inhibition of reverse transcription in vivo by elevated manganese ion concentration

25 November 2018

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DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change

25 November 2018

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Mechanisms of signaling and related enzymes

25 November 2018

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DNA polymerase beta: analysis of the contributions of tyrosine-271 and asparagine-279 to substrate specificity and fidelity of DNA replication by pre-steady-state kinetics

25 November 2018

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DNA polymerase beta: structure-fidelity relationship from Pre-steady-state kinetic analyses of all possible correct and incorrect base pairs for wild type and R283A mutant

25 November 2018

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Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

25 November 2018

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Structural insights into DNA polymerase beta fidelity: hold tight if you want it right

25 November 2018

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12 December 2020

Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity

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12 December 2020

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

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12 December 2020

A unified polymerase mechanism for nonhomologous DNA and RNA polymerases

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12 December 2020

Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity

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12 December 2020

Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates

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Infidelity of DNA synthesis in vitro: screening for potential metal mutagens or carcinogens

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12 December 2020

Identifiers

DOI

10.1021/BI061353Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17176036%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17176036%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

PubMed publication ID

17176036

1 reference