Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data (Q31121713)

29 June 2017

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title

Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data (English)

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29 June 2017

diabetic polyneuropathy

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Anders A F Sima

1

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29 June 2017

1 January 2007

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29 June 2017

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29 June 2017

21 Suppl 1

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29 June 2017

13-23; discussion 45-6

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https://scigraph.springernature.com/pub.10.2165/00023210-200721001-00003

29 June 2017

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The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications

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The roles of glucose-induced metabolic hypoxia and imbalances in carnitine metabolism in mediating diabetes-induced vascular dysfunction

21 January 2018

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Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy

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L-carnitine and acetyl-L-carnitine in human nerves from normal and diabetic subjects

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Diabetic neuropathy in the rat: 1. Alcar augments the reduced levels and axoplasmic transport of substance P.

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C-peptide induces a concentration-dependent dilation of skeletal muscle arterioles only in presence of insulin

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Axonal atrophy in sensory nerves of the diabetic BB-Wistar rat: a possible early correlate of human diabetic neuropathy

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Experimental diabetic neuropathy: an update

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A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats

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Improvement in nerve conduction following treatment in newly diagnosed diabetics

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Axo-glial dysjunction. A novel structural lesion that accounts for poorly reversible slowing of nerve conduction in the spontaneously diabetic bio-breeding rat

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Acetyl-L-carnitine corrects the altered peripheral nerve function of experimental diabetes

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12 December 2020

Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl-L-carnitine

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L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors

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12 December 2020

Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil

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12 December 2020

Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord

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12 December 2020

Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials

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12 December 2020

Reversible and irreversible nodal dysfunction in diabetic neuropathy

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12 December 2020

Tetrodotoxin-resistant sodium channels of dorsal root ganglion neurons are readily activated in diabetic rats.

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12 December 2020

Diabetic neuropathies

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Aldose reductase inhibitors: the end of an era or the need for different trial designs?

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Distal symmetric polyneuropathy in the spontaneously diabetic BB-wistar rat. An ultrastructural and teased fiber study

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

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Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group

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C-Peptide reverses nociceptive neuropathy in type 1 diabetes

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Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy

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C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB/Wor rats

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12 December 2020

Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study

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12 December 2020

Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats

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12 December 2020

Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy

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12 December 2020

Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration

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Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy.

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Unmyelinated fiber sensory neuropathy differs in type 1 and type 2 diabetes

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Does diabetes target ganglion neurones? Progressive sensory neurone involvement in long-term experimental diabetes.

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The interaction of long-chain acyl CoA with membranes

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C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes

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C-peptide and diabetic neuropathy

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Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin-dependent diabetes, and demonstration of axo-glial dysjunction in human diabetic neuropathy

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Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats

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New insights into the metabolic and molecular basis for diabetic neuropathy

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Aldose reductase inhibitors: therapeutic implications for diabetic complications

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Amelioration of Nerve Na+-K+-ATPase Activity Independently of myo-Inositol Level by PGE1 Analogue OP-1206 · α-CD in Streptozocin-Induced Diabetic Rats

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Diabetic neuropathy--a continuing enigma

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12 December 2020

Diabetic neuropathy and oxidative stress

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12 December 2020

Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat.

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12 December 2020

C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats.

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12 December 2020

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12 December 2020

Long-term effect of acetyl-L-carnitine on myocardial 123I-MIBG uptake in patients with diabetes

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12 December 2020

Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine

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12 December 2020

Effects of ALCAR on the fast axoplasmic transport in cultured sensory neurons of streptozotocin-induced diabetic rats

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12 December 2020

Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat

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12 December 2020

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12 December 2020

Reversible diabetic nerve dysfunction: structural correlates to electrophysiological abnormalities

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12 December 2020

Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats

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12 December 2020

Neurofilament and tubulin gene expression in progressive experimental diabetes: failure of synthesis and export by sensory neurons

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12 December 2020

Pathological mechanisms involved in diabetic neuropathy: can we slow the process?

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12 December 2020

Amelioration of sensory nerve dysfunction by C-Peptide in patients with type 1 diabetes

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12 December 2020

Early gene responses of trophic factors in nerve regeneration differ in experimental type 1 and type 2 diabetic polyneuropathies

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12 December 2020

Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy

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12 December 2020

Biological activity of C-peptide on the skin microcirculation in patients with insulin-dependent diabetes mellitus

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12 December 2020

Diabetic neuropathy differs in type 1 and type 2 diabetes

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12 December 2020

Alpha1-adrenoceptors involvement in painful diabetic neuropathy: a role in allodynia

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12 December 2020

Molecular alterations underlie nodal and paranodal degeneration in type 1 diabetic neuropathy and are prevented by C-peptide

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12 December 2020

Altered tubulin and neurofilament expression and impaired axonal growth in diabetic nerve regeneration

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12 December 2020

Changes in nodal function in nerve fibres of the spontaneously diabetic BB-Wistar rat: potential clamp analysis

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12 December 2020

Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications

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12 December 2020

Effect of endocrine pancreas allotransplantation on diabetic nerve dysfunction.

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12 December 2020

10.2165/00023210-200721001-00003

Identifiers

DOI

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PubMed ID

17696589

Dimensions Publication ID

29 June 2017

1033675551

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Fatcat ID

release_xgsxrhfbcfcctkqtnzkd56abfe

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Fatcat

https://api.fatcat.wiki/v0/release/xgsxrhfbcfcctkqtnzkd56abfe

24 November 2022

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PubMed ID

17696589

1 reference

PubMed ID

17696589