Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression (Q31139684)

29 June 2017

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression (English)

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29 June 2017

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1

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29 June 2017

2

Jesper Nylandsted

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29 June 2017

Marcel Leist

4

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Sam Brundin

series ordinal

6

object named as

Patrik Brundin

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29 June 2017

Marja Jäättelä

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ORCID Public Data File 2021

author name string

Roger F Castilho

series ordinal

3

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PubMed ID

12706247

29 June 2017

language of work or name

English

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publication date

1 April 2003

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29 June 2017

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29 June 2017

970

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29 June 2017

1-2

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29 June 2017

47-57

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Impairment of the ubiquitin-proteasome system by protein aggregation

29 June 2017

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https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2904275-0

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

7 January 2021

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Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

7 January 2021

1 reference

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Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

7 January 2021

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Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

7 January 2021

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

7 January 2021

1 reference

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

7 January 2021

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

7 January 2021

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

7 January 2021

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

7 January 2021

1 reference

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Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation

7 January 2021

1 reference

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Identification of genes that modify ataxin-1-induced neurodegeneration.

7 January 2021

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Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

7 January 2021

1 reference

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

7 January 2021

1 reference

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Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

7 January 2021

1 reference

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Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

7 January 2021

1 reference

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Additive Effects of Caspase Inhibitor and Lazaroid on the Survival of Transplanted Rat and Human Embryonic Dopamine Neurons

7 January 2021

1 reference

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

7 January 2021

1 reference

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

7 January 2021

1 reference

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A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections

7 January 2021

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Protein folding in vivo: unraveling complex pathways

7 January 2021

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Genetic suppression of polyglutamine toxicity in Drosophila

7 January 2021

1 reference

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Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

7 January 2021

1 reference

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Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

7 January 2021

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

7 January 2021

1 reference

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Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation

7 January 2021

1 reference

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

7 January 2021

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Roles of molecular chaperones in the nervous system

7 January 2021

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Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease

7 January 2021

1 reference

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Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2904275-0

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

7 January 2021

1 reference

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Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

7 January 2021

1 reference

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Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?

7 January 2021

1 reference

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Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

7 January 2021

1 reference

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Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

7 January 2021

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

7 January 2021

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Huntington's disease: the challenge for cell biologists

7 January 2021

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Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

7 January 2021

1 reference

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

7 January 2021

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Delaying the onset of Huntington's in mice

7 January 2021

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Anterior cingulate cortical transplantation in transgenic Huntington's disease mice

7 January 2021

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7 January 2021

1 reference

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Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

7 January 2021

1 reference

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Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

7 January 2021

1 reference

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

7 January 2021

1 reference

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

7 January 2021

1 reference

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7 January 2021

1 reference

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Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

7 January 2021

1 reference

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10.1016/S0006-8993(02)04275-0

7 January 2021

Identifiers

DOI

1 reference

release_lt7ntyilpvhqhg3nydpzft6sq4

29 June 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lt7ntyilpvhqhg3nydpzft6sq4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

12706247

1 reference

PubMed ID

12706247