Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR. (Q31778073)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134010%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR (English)

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3 November 2019

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1

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3 November 2019

author name string

Mathews MB

series ordinal

2

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3 November 2019

language of work or name

English

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publication date

27 December 2000

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134010%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

3 November 2019

published in

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3 November 2019

volume

276

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3 November 2019

page(s)

9936-9944

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3 November 2019

issue

13

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Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

3 November 2019

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1 reference

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A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.

21 January 2018

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Interactions between double-stranded RNA regulators and the protein kinase DAI

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Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR

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Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes

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PACT, a protein activator of the interferon-induced protein kinase, PKR.

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The double-stranded RNA-dependent protein kinase PKR: structure and function

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Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs.

21 January 2018

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Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR.

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P58IPK, a novel cochaperone containing tetratricopeptide repeats and a J-domain with oncogenic potential

21 January 2018

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Proteins binding to duplexed RNA: one motif, multiple functions

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Comparative genomics of the eukaryotes

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Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

21 January 2018

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Molecular basis of double-stranded RNA-protein interactions: structure of a dsRNA-binding domain complexed with dsRNA.

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A conserved double-stranded RNA-binding domain

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Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

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Functional characterization of the RNA-binding domain and motif of the double-stranded RNA-dependent protein kinase DAI (PKR).

21 January 2018

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Mechanism of interferon action motif I of the interferon-induced, RNA-dependent protein kinase (PKR) is sufficient to mediate RNA-binding activity

21 January 2018

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Mutational analysis of the double-stranded RNA (dsRNA) binding domain of the dsRNA-activated protein kinase, PKR.

21 January 2018

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Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells

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The regulation of the protein kinase PKR by RNA.

21 January 2018

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The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo

21 January 2018

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Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor

21 January 2018

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Interaction of the human protein kinase PKR with the mouse PKR homolog occurs via the N-terminal region of PKR and does not inactivate autophosphorylation activity of mouse PKR.

21 January 2018

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Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).

21 January 2018

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Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells

21 January 2018

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Localization of Epstein-Barr virus-encoded RNAs EBER-1 and EBER-2 in interphase and mitotic Burkitt lymphoma cells

21 January 2018

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Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18

21 January 2018

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The double-stranded RNA-binding protein X1rbpa promotes RNA strand annealing.

21 January 2018

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

21 January 2018

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RNA binding and modulation of PKR activity.

21 January 2018

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Two functionally distinct RNA-binding motifs in the regulatory domain of the protein kinase DAI

21 January 2018

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Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo

21 January 2018

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Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells

21 January 2018

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Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.

21 January 2018

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Specific mutations near the amino terminus of double-stranded RNA-dependent protein kinase (PKR) differentially affect its double-stranded RNA binding and dimerization properties

21 January 2018

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Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast

21 January 2018

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Structure and Function in the Nucleus

21 January 2018

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Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI

21 January 2018

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DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR

21 January 2018

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Like attracts like: getting RNA processing together in the nucleus

21 January 2018

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Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M007328200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134010%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference