BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors. (Q31813073)

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12 February 2020

title

BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors (English)

1 reference

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12 February 2020

1 reference

GOA release 2020-03-11

author

Stephanie Pangas

4

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12 February 2020

author name string

S K Tripurani

1

1 reference

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12 February 2020

R W Cook

2

1 reference

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12 February 2020

K W Eldin

3

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12 February 2020

language of work or name

English

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publication date

10 September 2012

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12 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22964636%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

32

1 reference

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12 February 2020

issue

33

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12 February 2020

page(s)

3877-3885

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Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development.

12 February 2020

cites work

1 reference

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SMAD3 and EGR1 physically and functionally interact in promoter-specific fashion

28 July 2018

1 reference

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Bone morphogenetic proteins and cancer: review of the literature

28 July 2018

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Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination

28 July 2018

1 reference

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Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors

28 July 2018

1 reference

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High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF.

28 July 2018

1 reference

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Role of platelet-derived growth factors in physiology and medicine

28 July 2018

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The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers

28 July 2018

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Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumors

28 July 2018

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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

28 July 2018

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Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice

28 July 2018

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Transcription of the platelet-derived growth factor A-chain gene

28 July 2018

1 reference

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Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.

28 July 2018

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Granulosa cell tumor of the ovary

28 July 2018

1 reference

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rVista for comparative sequence-based discovery of functional transcription factor binding sites

28 July 2018

1 reference

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NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525720

Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene

28 July 2018

1 reference

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Characterization of an immortalized human granulosa cell line (COV434).

28 July 2018

1 reference

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GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525720

Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.

28 July 2018

1 reference

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Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells

28 July 2018

1 reference

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Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1

28 July 2018

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TGFbeta signalling: a complex web in cancer progression

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.392

High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

Platelet-derived growth factor A-chain gene transcription is mediated by positive and negative regulatory regions in the promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

Platelet-derived growth factor (PDGF) and glial tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

Expression of c-kit and platelet-derived growth factor receptors in ovarian granulosa cell tumors

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.392

Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.392

TEX14 interacts with CEP55 to block cell abscission

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.392

Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.392

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.392

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22964636%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22964636%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22964636%20AND%20SRC:MED&resulttype=core&format=json