TGFbeta signalling: a complex web in cancer progression (Q37760038)

22 August 2017

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title

TGFbeta signalling: a complex web in cancer progression (English)

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22 August 2017

Hiroaki Ikushima

1

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22 August 2017

Kohei Miyazono

series ordinal

2

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22 August 2017

language of work or name

English

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publication date

1 June 2010

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22 August 2017

Nature Reviews Cancer

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22 August 2017

10

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22 August 2017

6

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22 August 2017

415-424

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https://scigraph.springernature.com/pub.10.1038/nrc2853

22 August 2017

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cites work

Role of transforming growth factor beta in human disease

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Alterations in components of the TGF-beta superfamily signaling pathways in human cancer

31 March 2020

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

31 March 2020

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High levels of transforming growth factor beta 1 in patients with colorectal cancer: association with disease progression

31 March 2020

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Transforming growth factor beta1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer

31 March 2020

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Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

31 March 2020

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Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

31 March 2020

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Transforming growth factor-beta regulation of immune responses

31 March 2020

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

31 March 2020

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

31 March 2020

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Specificity and versatility in tgf-beta signaling through Smads

31 March 2020

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Making sense of latent TGFbeta activation

31 March 2020

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Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability

31 March 2020

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Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

31 March 2020

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Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth

31 March 2020

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

31 March 2020

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Two major Smad pathways in TGF-beta superfamily signalling.

31 March 2020

1 reference

Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.

31 March 2020

1 reference

Promoter-wide analysis of Smad4 binding sites in human epithelial cells.

31 March 2020

1 reference

An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling

31 March 2020

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31 March 2020

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Cellular context-dependent "colors" of transforming growth factor-beta signaling

31 March 2020

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TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

31 March 2020

1 reference

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

31 March 2020

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E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

31 March 2020

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Non-Smad TGF-beta signals

31 March 2020

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Non-Smad pathways in TGF-beta signaling

31 March 2020

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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

31 March 2020

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

31 March 2020

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c-myc is a downstream target of the Smad pathway

31 March 2020

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4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation

31 March 2020

1 reference

Ski and SnoN, potent negative regulators of TGF-beta signaling

31 March 2020

1 reference

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements

31 March 2020

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SnoN functions as a tumour suppressor by inducing premature senescence

31 March 2020

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Dual role of SnoN in mammalian tumorigenesis

31 March 2020

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Ski promotes tumor growth through abrogation of transforming growth factor-beta signaling in pancreatic cancer

31 March 2020

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Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26

31 March 2020

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The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

31 March 2020

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SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells

31 March 2020

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Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6

31 March 2020

2 references

31 March 2020

12 December 2020

BCL6 represses Smad signaling in transforming growth factor-beta resistance

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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

31 March 2020

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Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element

31 March 2020

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RUNX transcription factors as key targets of TGF-beta superfamily signaling

31 March 2020

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RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.

31 March 2020

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The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

31 March 2020

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TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

31 March 2020

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High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene.

31 March 2020

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Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors

31 March 2020

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TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase

31 March 2020

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Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

31 March 2020

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Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells

31 March 2020

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Bim is a suppressor of Myc-induced mouse B cell leukemia

31 March 2020

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Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1

31 March 2020

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Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1alpha) and the HIF-1alpha target gene DEC1, but not lymph node metastasis in primary human breast carcinomas

31 March 2020

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The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers

31 March 2020

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Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.

31 March 2020

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The paradox of autophagy and its implication in cancer etiology and therapy

31 March 2020

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Stem cells, cancer, and cancer stem cells

31 March 2020

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Cancer stem cells and their niche

31 March 2020

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TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

31 March 2020

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Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model

31 March 2020

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The epithelial-mesenchymal transition generates cells with properties of stem cells

31 March 2020

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Roles of TGF-beta family signaling in stem cell renewal and differentiation

31 March 2020

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TGF-beta, neuronal stem cells and glioblastoma

31 March 2020

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TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.

31 March 2020

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Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.

31 March 2020

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Pairing SOX off: with partners in the regulation of embryonic development

31 March 2020

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SOX2 functions to maintain neural progenitor identity

31 March 2020

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Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain

31 March 2020

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

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Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

31 March 2020

1 reference

Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies

31 March 2020

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Noggin antagonizes BMP signaling to create a niche for adult neurogenesis

31 March 2020

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Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

31 March 2020

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Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells

31 March 2020

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TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

31 March 2020

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Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

31 March 2020

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Excessive production of transforming growth-factor beta 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth

31 March 2020

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A multigenic program mediating breast cancer metastasis to bone

31 March 2020

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Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

31 March 2020

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TGF-beta signaling in tumor suppression and cancer progression

31 March 2020

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Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

31 March 2020

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Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling

31 March 2020

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c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.

31 March 2020

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Epithelial-mesenchymal transitions in tumour progression

31 March 2020

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Epithelial-mesenchymal transitions in development and disease

31 March 2020

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Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

31 March 2020

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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

31 March 2020

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

31 March 2020

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TGF-beta-induced epithelial to mesenchymal transition

31 March 2020

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

31 March 2020

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Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

31 March 2020

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TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.

31 March 2020

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Role of Ras signaling in the induction of snail by transforming growth factor-beta.

31 March 2020

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TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

31 March 2020

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

31 March 2020

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Smad signaling is required to maintain epigenetic silencing during breast cancer progression.

31 March 2020

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BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

31 March 2020

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Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer

31 March 2020

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BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo

31 March 2020

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Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells

31 March 2020

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Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors

31 March 2020

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SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains

31 March 2020

1 reference

Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: a high-throughput tissue microarray and immunohistochemistry study.

31 March 2020

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TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

31 March 2020

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Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

31 March 2020

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TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

31 March 2020

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Cyclic adenosine monophosphate/protein kinase A mediates parathyroid hormone/parathyroid hormone-related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cells

31 March 2020

1 reference

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

31 March 2020

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Molecular biology of bone metastasis

31 March 2020

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Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line.

31 March 2020

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Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor

31 March 2020

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Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor- Type I Receptor Kinase In vivo

31 March 2020

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The two faces of transforming growth factor beta in carcinogenesis

31 March 2020

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Development of TGF-beta signalling inhibitors for cancer therapy

31 March 2020

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Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009.

31 March 2020

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Identification of multipotent mesenchymal stromal cells in the reactive stroma of a prostate cancer xenograft by side population analysis

31 March 2020

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Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.

31 March 2020

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Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma

31 March 2020

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12 December 2020

Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model

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12 December 2020

A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells

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12 December 2020

A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1.

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12 December 2020

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer

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12 December 2020

SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells

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12 December 2020

Role of interleukin 10 and transforming growth factor beta1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice

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12 December 2020

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

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12 December 2020

Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma

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12 December 2020

Identifiers

DOI

10.1038/NRC2853

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release_uscgubwegrd4vnask3746gcx5q

22 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/uscgubwegrd4vnask3746gcx5q

24 November 2022

mapped directly with Wikidata item

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