Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells (Q33183746)

23 July 2017

title

Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells (English)

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23 July 2017

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1

Clarissa von Haefen

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23 July 2017

Thomas Wieder

2

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23 July 2017

Bernd Gillissen

3

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23 July 2017

Lilian Stärck

4

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23 July 2017

Vilma Graupner

5

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23 July 2017

Bernd Dörken

6

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23 July 2017

Peter T Daniel

7

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23 July 2017

language of work or name

English

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publication date

1 June 2002

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23 July 2017

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23 July 2017

volume

21

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23 July 2017

issue

25

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23 July 2017

page(s)

4009-4019

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The Bcl-2 protein family: arbiters of cell survival

23 July 2017

cites work

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Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice

21 January 2018

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Cell death beyond apoptosis

21 January 2018

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Dissecting the pathways to death

21 January 2018

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

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Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features

21 January 2018

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

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The vitamin D3 analogue, calcipotriol, induces sphingomyelin hydrolysis in human keratinocytes

21 January 2018

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1alpha,25-dihydroxyvitamin D3 induces sphingomyelin hydrolysis in HaCaT cells via tumor necrosis factor alpha

21 January 2018

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Ceramide signalling: regulatory role in cell proliferation, differentiation and apoptosis in human epidermis

21 January 2018

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Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA.

21 January 2018

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Ceramide in the eukaryotic stress response

21 January 2018

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Activation of a nuclear sphingomyelinase in radiation-induced apoptosis

21 January 2018

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Bax-dependent apoptosis induced by ceramide in HL-60 cells

21 January 2018

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Regulation of ceramide production and apoptosis

21 January 2018

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CD95's deadly mission in the immune system

21 January 2018

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Mitochondrial control of cell death

21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

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ATM dependent apoptosis in the nervous system

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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Sphingomyelinases in cell regulation

21 January 2018

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Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

21 January 2018

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Lipid signaling in CD95-mediated apoptosis

21 January 2018

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Breaking the mitochondrial barrier

21 January 2018

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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis

21 January 2018

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Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo

21 January 2018

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The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines

21 January 2018

1 reference

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Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release

21 January 2018

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The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis

21 January 2018

1 reference

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Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.

21 January 2018

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Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.

21 January 2018

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Measurement of protein using bicinchoninic acid

21 January 2018

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prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.

21 January 2018

1 reference

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Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases

21 January 2018

1 reference

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Analysis of p53/BAX/p16(ink4a/CDKN2) in esophageal squamous cell carcinoma: high BAX and p16(ink4a/CDKN2) identifies patients with good prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

Overexpression of the death-promoting gene bax-alpha sensitizes human BL-41 Burkitt lymphoma cells for surface IgM-mediated apoptosis

21 January 2018

1 reference

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Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

Role of BAX in the apoptotic response to anticancer agents

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis

21 January 2018

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

Ceramide Induces CytochromecRelease from Isolated Mitochondria

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

21 January 2018

Apoptosis in development

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

7 January 2021

Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

7 January 2021

High-titer packaging cells producing recombinant retroviruses resistant to human serum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

7 January 2021

Signal transduction pathways that regulate cell survival and cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

7 January 2021

Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

7 January 2021

Programmed cell death induced by ceramide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

7 January 2021

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

7 January 2021

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c rel

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205497

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205497

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Dimensions Publication ID

23 July 2017

1010199811

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1 reference