Optimized expression and specific activity of IL-12 by directed molecular evolution (Q33185720)

23 July 2017

Optimized expression and specific activity of IL-12 by directed molecular evolution (English)

1 reference

23 July 2017

Steven R Leong

1

1 reference

23 July 2017

Jean C C Chang

2

1 reference

23 July 2017

Randal Ong

3

1 reference

23 July 2017

Glenn Dawes

4

1 reference

23 July 2017

Willem P C Stemmer

5

1 reference

23 July 2017

Juha Punnonen

6

1 reference

23 July 2017

language of work or name

English

0 references

publication date

15 January 2003

1 reference

23 July 2017

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

23 July 2017

100

1 reference

23 July 2017

3

1 reference

23 July 2017

1163-1168

1 reference

Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cells

23 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Adapting pharmacokinetic properties of a humanized anti-interleukin-8 antibody for therapeutic applications using site-specific pegylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

DNA shuffling and vaccines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Breeding of retroviruses by DNA shuffling for improved stability and processing yields

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Molecular breeding: the natural approach to protein design

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

DNA shuffling of subgenomic sequences of subtilisin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Evolution of a cytokine using DNA family shuffling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Interleukin-12 therapy of cutaneous T-cell lymphoma induces lesion regression and cytotoxic T-cell responses.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Selection for neutralization resistance of the simian/human immunodeficiency virus SHIVSF33A variant in vivo by virtue of sequence changes in the extracellular envelope glycoprotein that modify N-linked glycosylation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis C.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Gene gun-mediated IL-12 gene therapy induces antitumor effects in the absence of toxicity: a direct comparison with systemic IL-12 protein therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Interleukin-12: basic principles and clinical applications.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Interleukin 12 deficiency associated with recurrent infections

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Appropriate mammalian expression systems for biopharmaceuticals.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Administration of recombinant human interleukin 12 to chronically SIVmac-infected rhesus monkeys

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

DNA shuffling of a family of genes from diverse species accelerates directed evolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Initiation of T-helper cell immunity to Candida albicans by IL-12: the role of neutrophils

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Immune-mediated side-effects of cytokines in humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Immunogenicity of a mammalian cell-derived recombinant human growth hormone preparation during long-term treatment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Cloning and expression of murine IL-12

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Long-lived protective immunity to Listeria is conferred by immunization with particulate or soluble listerial antigen preparations coadministered with IL-12.

21 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0237327100

Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a phase I study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0237327100

Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0237327100

Evaluation of IL-12 in immunotherapy and vaccine design in experimental Mycobacterium avium infections.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Increased susceptibility to postoperative sepsis in patients with impaired monocyte IL-12 production.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

IL-12 gene therapy protects mice in lethal Klebsiella pneumonia.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298744

IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans

31 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0237327100

Production of interleukin-12 as a self-processing 2A polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0237327100

Monocyte-derived CD1a+ and CD1a- dendritic cell subsets differ in their cytokine production profiles, susceptibilities to transfection, and capacities to direct Th cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0237327100

Glycosylation of the overlapping sequons in yeast external invertase: effect of amino acid variation on site selectivity in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0237327100

A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis B

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0237327100

Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis

21 January 2018

1 reference

12 December 2020

1 reference

12 December 2020

IL-13 induces proliferation, Ig isotype switching, and Ig synthesis by immature human fetal B cells

1 reference

12 December 2020

Biologic effects of recombinant human interleukin-12 in squirrel monkeys (Sciureus saimiri)

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of recombinant human interleukin-12 in male rhesus monkeys

1 reference

12 December 2020

Molecular model of interleukin 12 that highlights amino acid sequence homologies with adhesion domains and gastrointestinal peptides

1 reference

12 December 2020

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen

1 reference

12 December 2020

Immunological effects of interleukin 12 administered by bolus intravenous injection to patients with cancer

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0237327100

1 reference

23 July 2017

0 references

1 reference

23 July 2017

1 reference