Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis (Q33229065)

24 July 2017

title

Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis (English)

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24 July 2017

Malet G

1

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24 July 2017

Martín AG

2

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24 July 2017

Orzáez M

3

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24 July 2017

Vicent MJ

4

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24 July 2017

Masip I

5

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24 July 2017

Sanclimens G

6

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24 July 2017

Ferrer-Montiel A

7

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24 July 2017

Mingarro I

8

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24 July 2017

Messeguer A

9

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24 July 2017

Fearnhead HO

10

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24 July 2017

Pérez-Payá E

11

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24 July 2017

publication date

9 December 2005

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Cell Death & Differentiation

24 July 2017

published in

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24 July 2017

volume

13

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24 July 2017

issue

9

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24 July 2017

page(s)

1523-1532

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Apoptosis-regulating proteins as targets for drug discovery

24 July 2017

cites work

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Caspase-9 and APAF-1 form an active holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Inhibition of human caspases by peptide-based and macromolecular inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Direct activation of the apoptosis machinery as a mechanism to target cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Peptoids: a modular approach to drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

A positional scanning combinatorial library of peptoids as a source of biological active molecules: identification of antimicrobials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Attenuation of thermal nociception and hyperalgesia by VR1 blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Design and synthesis of an optimized positional scanning library of peptoids: identification of novel multidrug resistance reversal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Identification of peptides that neutralize bacterial endotoxins using beta-hairpin conformationally restricted libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Membrane binding and translocation of cell-penetrating peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

The antennapedia peptide penetratin translocates across lipid bilayers - the first direct observation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

The dawning era of polymer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Fractionation and characterization of a conjugate between a polymeric drug-carrier and the antitumor drug camptothecin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Potent and selective nonpeptide inhibitors of caspases 3 and 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Peptomers: a versatile approach for the preparation of diverse combinatorial peptidomimetic bead libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Oncogene-dependent apoptosis is mediated by caspase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

inferred from DOI database lookup

7 January 2021

based on heuristic

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

inferred from DOI database lookup

7 January 2021

based on heuristic

Cell-free systems to study apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401828

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.CDD.4401828

1 reference

Dimensions Publication ID

24 July 2017

1005096590

0 references

1 reference