Diversity-oriented synthesis: exploring the intersections between chemistry and biology (Q33231454)

24 July 2017

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title

Diversity-oriented synthesis: exploring the intersections between chemistry and biology (English)

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24 July 2017

Derek S Tan

1

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24 July 2017

1 July 2005

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24 July 2017

Nature Chemical Biology

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24 July 2017

1

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24 July 2017

2

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24 July 2017

74-84

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https://scigraph.springernature.com/pub.10.1038/nchembio0705-74

24 July 2017

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21 January 2018

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Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

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Chemical space and biology

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Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC).

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Current progress in natural product-like libraries for discovery screening

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Cell-based partitioning

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Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

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Dimethylzinc-mediated additions of alkenylzirconocenes to aldimines. New methodologies for allylic amine and C-cyclopropylalkylamine syntheses

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A homo [3+2] dipolar cycloaddition: the reaction of nitrones with cyclopropanes

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Three-component homo 3 + 2 dipolar cycloaddition. A diversity-oriented synthesis of tetrahydro-1,2-oxazines and FR900482 skeletal congeners

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A three-component reaction for diversity-oriented synthesis of polysubstituted piperidines: solution and solid-phase optimization of the first tandem aza[4+2]/allylboration

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Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons

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Small molecules that induce cardiomyogenesis in embryonic stem cells

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Identifiers

DOI

10.1038/NCHEMBIO0705-74

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24 July 2017

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PubMed ID

16408003