Diversification and specialization of HIV protease function during in vitro evolution (Q33232096)

24 July 2017

Diversification and specialization of HIV protease function during in vitro evolution (English)

1 reference

24 July 2017

Taryn L O'Loughlin

1

1 reference

PubMed ID

16423863

24 July 2017

Dina N Greene

series ordinal

2

1 reference

PubMed ID

16423863

24 July 2017

Ichiro Matsumura

series ordinal

3

1 reference

24 July 2017

19 January 2006

1 reference

Molecular Biology and Evolution

24 July 2017

1 reference

24 July 2017

23

1 reference

24 July 2017

4

1 reference

24 July 2017

764-772

1 reference

Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.

24 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

The 'evolvability' of promiscuous protein functions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Resurrecting ancient genes: experimental analysis of extinct molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Rapid evolution of beta-glucuronidase specificity by saturation mutagenesis of an active site loop

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Adaptive evolution of genes and gene families

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Recombination studies of lactose nonfermenting mutants of Escherichia coli K-12

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

A perspective on enzyme catalysis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

In vitro evolution of beta-glucuronidase into a beta-galactosidase proceeds through non-specific intermediates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Statistical methods for detecting molecular adaptation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Directed evolution of an aspartate aminotransferase with new substrate specificities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

The structural basis of molecular adaptation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Human immunodeficiency virus protease ligand specificity conferred by residues outside of the active site cavity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Rapid evolution of a protein in vitro by DNA shuffling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Active human immunodeficiency virus protease is required for viral infectivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

High efficiency transformation of E. coli by high voltage electroporation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Isolation of mutants of human immunodeficiency virus protease based on the toxicity of the enzyme in Escherichia coli

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

beta-Galactosidase containing a human immunodeficiency virus protease cleavage site is cleaved and inactivated by human immunodeficiency virus protease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Randomization of genes by PCR mutagenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

HIV-1 protease variants from 100-fold drug resistant clinical isolates: expression, purification, and crystallization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2012945

Conformational diversity and protein evolution--a 60-year-old hypothesis revisited

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16423863

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell killing by HIV-1 protease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16423863

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/MOLBEV/MSJ098

1 reference

24 July 2017

1 reference

24 July 2017

1 reference

PubMed ID

16423863