Conformational diversity and protein evolution--a 60-year-old hypothesis revisited (Q73702393)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

Conformational diversity and protein evolution--a 60-year-old hypothesis revisited (English)

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6 November 2019

author name string

Leo C James

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Dan S Tawfik

series ordinal

2

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6 November 2019

publication date

1 July 2003

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6 November 2019

number of pages

8

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Trends in Biochemical Sciences

inferred from page(s)

published in

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6 November 2019

volume

28

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

page(s)

361-368

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6 November 2019

issue

7

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Conformational changes affect binding and catalysis by ester-hydrolysing antibodies.

6 November 2019

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An evolutionary bridge to a new protein fold.

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Conformational diversity in a yeast prion dictates its seeding specificity

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Natively unfolded proteins: a point where biology waits for physics

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Intrinsically unstructured proteins

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Multiple conformational changes in enzyme catalysis

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Flexibility, conformational diversity and two dimerization modes in complexes of ribosomal protein L12

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Kinetic evidence for hapten-induced conformational transition in immunoglobin MOPC 460

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Equilibrium and rate constants for the interconversion of two conformations of -chymotrypsin. The existence of a catalytically inactive conformation at neutral p H

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Antibody multispecificity mediated by conformational diversity

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Structure and dynamics of the alpha-lactalbumin molten globule: fluorescence studies using proteins containing a single tryptophan residue

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Memory landscapes of single-enzyme molecules

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Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

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Catalytic promiscuity and the evolution of new enzymatic activities

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Enzymes with extra talents: moonlighting functions and catalytic promiscuity

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Off-the-shelf proteins that rival tailor-made antibodies as catalysts.

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Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

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The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis

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The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site

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Structural and physicochemical analysis of the reaction between the anti-lysozyme antibody D1.3 and the anti-idiotopic antibodies E225 and E5.2

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7 January 2021

Man-made enzymes--from design to in vitro compartmentalisation

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The search for the ideal biocatalyst.

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Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family

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Rapid evolution of bacterial catabolic enzymes: a case study with atrazine chlorohydrolase

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Enzyme recruitment in evolution of new function

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Moonlighting proteins.

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Evolutionary chemistry: getting there from here

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Gradual development of protein-like global structures through functional selection

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Distinct stages of protein evolution as suggested by protein sequence analysis

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In vitro evolution of beta-glucuronidase into a beta-galactosidase proceeds through non-specific intermediates

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Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways

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7 January 2021

Alteration of Cre recombinase site specificity by substrate-linked protein evolution.

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7 January 2021

A Theory of the Structure and Process of Formation of Antibodies*

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Antibody framework residues affecting the conformation of the hypervariable loops

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12878003%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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