Technology insight: Utility of TNF-alpha-based isolated limb perfusion to avoid amputation of irresectable tumors of the extremities (Q33233270)

24 July 2017

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title

Technology insight: Utility of TNF-alpha-based isolated limb perfusion to avoid amputation of irresectable tumors of the extremities (English)

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24 July 2017

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4

Alexander M M Eggermont

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24 July 2017

Dirk J Grünhagen

1

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Timo L M ten Hagen

series ordinal

3

object named as

Timo L M ten Hagen

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24 July 2017

2

Johannes H W de Wilt

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24 July 2017

publication date

1 February 2006

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Nature Clinical Practice Oncology

24 July 2017

published in

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24 July 2017

volume

3

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24 July 2017

issue

2

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24 July 2017

page(s)

94-103

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Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts

24 July 2017

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High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma

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Isolated limb perfusion with high-dose tumor necrosis factor-alpha in combination with interferon-gamma and melphalan for nonresectable extremity soft tissue sarcomas: a multicenter trial

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Re-evaluating the role of dacarbazine in metastatic melanoma: what have we learned in 30 years?

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Regional therapy of melanoma

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Treatment of patients with melanoma of the extremity using hyperthermic isolated limb perfusion with melphalan, tumor necrosis factor, and interferon gamma: results of a tumor necrosis factor dose-escalation study

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High dose tumor necrosis factor-alpha and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a >90% response rate and limb preservation

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7 January 2021

Feasibility and efficacy of external beam radiotherapy after hyperthermic isolated limb perfusion with TNF-alpha and melphalan for limb-saving treatment in locally advanced extremity soft-tissue sarcoma

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Hyperthermic isolated limb perfusion with tumour necrosis factor-alpha and melphalan as palliative limb-saving treatment in patients with locally advanced soft-tissue sarcomas of the extremities with regional or distant metastases. Is it worthwhile?

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7 January 2021

Soft tissue limb sarcomas

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7 January 2021

Multifocal soft tissue sarcoma: limb salvage following hyperthermic isolated limb perfusion with high-dose tumor necrosis factor and melphalan

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7 January 2021

Limb desmoid tumors: a possible role for isolated limb perfusion with tumor necrosis factor-alpha and melphalan

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7 January 2021

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Isolated limb perfusion with tumor necrosis factor and melphalan prevents amputation in patients with multiple sarcomas in arm or leg.

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7 January 2021

Isolated limb perfusions with tumor necrosis factor and melphalan for locally recurrent soft tissue sarcoma in previously irradiated limbs.

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7 January 2021

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7 January 2021

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7 January 2021

Hyperthermic Isolated Perfusion With Low-Dose Tumor Necrosis Factor α and Doxorubicin for the Treatment of Limb-Threatening Soft Tissue Sarcomas

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7 January 2021

Limb salvage with isolated perfusion for soft tissue sarcoma: could less TNF-alpha be better?

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Systemic toxicity and cytokine/acute phase protein levels in patients after isolated limb perfusion with tumor necrosis factor-alpha complicated by high leakage

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

One hundred consecutive isolated limb perfusions with TNF-alpha and melphalan in melanoma patients with multiple in-transit metastases

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7 January 2021

Hyperthermic Isolated Limb Perfusion With Low-Dose Tumor Necrosis Factor-α and Melphalan for Bulky In-Transit Melanoma Metastases

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7 January 2021

Efficacy of repeat isolated limb perfusions with tumor necrosis factor alpha and melphalan for multiple in-transit metastases in patients with prior isolated limb perfusion failure

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7 January 2021

Hyperthermic isolated limb perfusion with tumor necrosis factor alpha, interferon gamma, and melphalan for locally advanced nonmelanoma skin tumors of the extremities: a multicenter study

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7 January 2021

Isolated limb perfusion with tumour necrosis factor-alpha and melphalan for unresectable bone sarcomas of the lower extremity

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7 January 2021

31P magnetic resonance spectroscopy as predictor of clinical response in human extremity sarcomas treated by single dose TNF-alpha + melphalan isolated limb perfusion

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7 January 2021

Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma

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7 January 2021

Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNF alpha)

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7 January 2021

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

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7 January 2021

TNF-alpha augments intratumoural concentrations of doxorubicin in TNF-alpha-based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects

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7 January 2021

Degree of tumour vascularity correlates with drug accumulation and tumour response upon TNF-alpha-based isolated hepatic perfusion

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7 January 2021

Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: preclinical studies

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7 January 2021

Synergistic antitumor response of interleukin 2 with melphalan in isolated limb perfusion in soft tissue sarcoma-bearing rats

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7 January 2021

Low-dose tumor necrosis factor-alpha augments antitumor activity of stealth liposomal doxorubicin (DOXIL) in soft tissue sarcoma-bearing rats

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7 January 2021

Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics

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7 January 2021

TNF is here to stay--revisited

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7 January 2021

Identifiers

DOI

10.1038/NCPONC0426

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24 July 2017

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