Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter. (Q33257856)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16981002%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

title

Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter (English)

1 reference

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30 December 2019

2

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30 December 2019

Richard Callaghan

series ordinal

3

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30 December 2019

author name string

R Clark

series ordinal

1

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30 December 2019

language of work or name

English

0 references

publication date

18 September 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16981002%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Pharmacology

30 December 2019

published in

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30 December 2019

volume

149

1 reference

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30 December 2019

issue

5

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30 December 2019

page(s)

506-515

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16981002%20AND%20SRC:MED&resulttype=core&format=json

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

30 December 2019

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BCRP/ABCG2 levels account for the resistance to topoisomerase I inhibitors and reversal effects by gefitinib in non-small cell lung cancer.

21 June 2018

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Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues.

21 June 2018

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21 June 2018

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21 June 2018

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Mutational analysis of ABCG2: role of the GXXXG motif

21 June 2018

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Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

21 June 2018

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The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

21 June 2018

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ABCG2 -- a transporter for all seasons

21 June 2018

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Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2.

21 June 2018

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The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

21 June 2018

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The Role of ABC Transporters in Clinical Practice

21 June 2018

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ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion

21 June 2018

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Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors

21 June 2018

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A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

21 June 2018

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Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation

21 June 2018

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Multidrug resistance and cancer: the role of the human ABC transporter ABCG2.

21 June 2018

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Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material

21 June 2018

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Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2.

21 June 2018

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A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance

21 June 2018

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Multidrug resistance in cancer: role of ATP-dependent transporters

21 June 2018

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Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization

21 June 2018

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Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein

21 June 2018

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21 June 2018

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The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

21 June 2018

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P-glycoprotein levels predict poor outcome in patients with osteosarcoma

21 June 2018

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The prognostic significance of membrane transport-associated multidrug resistance (MDR) proteins in leukemia

21 June 2018

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The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

21 June 2018

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Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes

21 June 2018

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A multidrug resistance transporter from human MCF-7 breast cancer cells

21 June 2018

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A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance

21 June 2018

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Herpes simplex virus inhibitor ICP47 destabilizes the transporter associated with antigen processing (TAP) heterodimer

21 June 2018

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21 June 2018

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Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

21 June 2018

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P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 June 2018

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The kinetics of competitive radioligand binding predicted by the law of mass action.

21 June 2018

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Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

21 June 2018

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Molecular pharmacology of the calcium channel: evidence for subtypes, multiple drug-receptor sites, channel subunits, and the development of a radioiodinated 1,4-dihydropyridine calcium channel label, [125I]iodipine.

21 June 2018

1 reference

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P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma

21 June 2018

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Mouse liver PMP70 and ALDP: homomeric interactions prevail in vivo.

21 June 2018

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Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers.

21 January 2018

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Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.

31 October 2018

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Breast cancer resistance protein and P-glycoprotein in 149 adult acute myeloid leukemias

31 October 2018

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Order changes within receptor systems upon ligand binding: receptor tightening/oligomerisation and the interpretation of binding parameters

31 October 2018

1 reference

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Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

31 October 2018

1 reference

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Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

31 October 2018

1 reference

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A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).

31 October 2018

1 reference

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Communication between multiple drug binding sites on P-glycoprotein

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16981002

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16981002

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJP.0706904

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16981002%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16981002%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference