The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein. (Q40546719)

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29 December 2019

title

The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein (English)

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29 December 2019

main subject

transmembrane protein

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author

Ian D. Kerr

5

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29 December 2019

Alice Rothnie

1

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29 December 2019

Richard Callaghan

6

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29 December 2019

author name string

Janet Storm

2

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29 December 2019

Jeff Campbell

3

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29 December 2019

Kenneth J Linton

4

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29 December 2019

language of work or name

English

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publication date

10 June 2004

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Journal of Biological Chemistry

29 December 2019

published in

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29 December 2019

volume

279

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29 December 2019

issue

33

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29 December 2019

page(s)

34913-34921

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Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

29 December 2019

cites work

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P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

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Mechanism of free energy coupling in active transport

21 January 2018

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The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein

21 January 2018

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Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

21 January 2018

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Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

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Characterization and functional reconstitution of the multidrug transporter.

21 January 2018

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Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

21 January 2018

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Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity.

21 January 2018

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Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

21 January 2018

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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

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Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

21 January 2018

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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

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Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation

21 January 2018

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The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

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Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane

21 January 2018

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An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

21 January 2018

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Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

21 January 2018

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A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

21 January 2018

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Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

21 January 2018

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Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning

21 January 2018

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Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein

21 January 2018

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Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

21 January 2018

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Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

21 January 2018

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Cysteine-scanning mutagenesis provides no evidence for the extracellular accessibility of the nucleotide-binding domains of the multidrug resistance transporter P-glycoprotein

21 January 2018

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Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein

21 January 2018

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Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508.

21 January 2018

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Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

21 January 2018

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Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

21 January 2018

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Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

21 January 2018

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Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.

21 January 2018

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Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

21 January 2018

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

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Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

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Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

21 January 2018

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Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M405336200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192095%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference