The evolution of catalytic efficiency and substrate promiscuity in human theta class 1-1 glutathione transferase (Q33258955)

24 July 2017

title

The evolution of catalytic efficiency and substrate promiscuity in human theta class 1-1 glutathione transferase (English)

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24 July 2017

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Karl E Griswold

1

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author name string

Nandini S Aiyappan

series ordinal

2

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24 July 2017

Brent L Iverson

series ordinal

3

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24 July 2017

George Georgiou

series ordinal

4

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24 July 2017

language of work or name

English

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publication date

9 September 2006

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Journal of Molecular Biology

24 July 2017

published in

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24 July 2017

volume

364

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24 July 2017

issue

3

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24 July 2017

page(s)

400-410

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Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

24 July 2017

cites work

1 reference

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14 July 2018

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Evolution of highly active enzymes by homology-independent recombination

14 July 2018

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14 July 2018

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14 July 2018

Glutathione transferases

1 reference

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Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

14 July 2018

1 reference

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The 'evolvability' of promiscuous protein functions

14 July 2018

1 reference

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Directed enzyme evolution guided by multidimensional analysis of substrate-activity space

14 July 2018

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14 July 2018

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Forced Evolution of a Herbicide Detoxifying Glutathione Transferase

14 July 2018

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14 July 2018

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An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes

14 July 2018

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Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Catalytic promiscuity and the evolution of new enzymatic activities

14 July 2018

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Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling

14 July 2018

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Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions

14 July 2018

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14 July 2018

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Site-saturation mutagenesis is more efficient than DNA shuffling for the directed evolution of beta-fucosidase from beta-galactosidase

14 July 2018

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Engineering glutathione transferase to a novel glutathione peroxidase mimic with high catalytic efficiency. Incorporation of selenocysteine into a glutathione-binding scaffold using an auxotrophic expression system

31 October 2018

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31 October 2018

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.JMB.2006.09.012

1 reference

24 July 2017

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24 July 2017

1 reference