'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. (Q33266778)

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23 December 2019

title

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737 (English)

1 reference

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23 December 2019

6

1 reference

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23 December 2019

author name string

X Lin

1

1 reference

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23 December 2019

S Morgan-Lappe

2

1 reference

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23 December 2019

X Huang

3

1 reference

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23 December 2019

L Li

4

1 reference

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23 December 2019

D M Zakula

5

1 reference

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23 December 2019

S W Fesik

7

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23 December 2019

Y Shen

8

1 reference

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23 December 2019

language of work or name

English

0 references

publication date

18 December 2006

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23 December 2019

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23 December 2019

volume

26

1 reference

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23 December 2019

issue

27

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23 December 2019

page(s)

3972-3979

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3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

23 December 2019

cites work

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Cell death: critical control points

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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The role of Bcl-2 family members in tumorigenesis

21 January 2018

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siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

21 January 2018

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The genetics of RNA silencing

21 January 2018

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Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels

21 January 2018

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Gene silencing as an adaptive defence against viruses

21 January 2018

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The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

21 January 2018

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