The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled (Q33267326)

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English	The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

Dishevelled Dmel_CG18361

1 reference

GOA release 2020-03-11

Notch Dmel_CG3936

1 reference

GOA release 2020-03-11

author name string

Ana Carmena

1

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

Stephan Speicher

2

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Europe PubMed Central

PubMed publication ID

24 July 2017

Mary Baylies

3

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

language of work or name

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publication date

20 December 2006

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Europe PubMed Central

PubMed publication ID

24 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

e66

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

copyright license

Creative Commons Attribution 4.0 International

20 December 2006

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Wnt signaling: is the party in the nucleus?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats

1 reference

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21 June 2018

The love-hate relationship between Ras and Notch.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

The roles of receptor and ligand endocytosis in regulating Notch signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

The Wnt signaling pathway in development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

The AF-6 Homolog Canoe Acts as a Rap1 Effector During Dorsal Closure of the Drosophila Embryo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Notch activation of yan expression is antagonized by RTK/pointed signaling in the Drosophila eye.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Invertebrate myogenesis: looking back to the future of muscle development

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21 June 2018

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

PDZ domains and the organization of supramolecular complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Signaling networks: the origins of cellular multitasking

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Controls in patterning and diversification of somatic muscles during Drosophila embryogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Dishevelled: at the crossroads of divergent intracellular signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

In vivo interaction of AF-6 with activated Ras and ZO-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

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Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins

1 reference

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Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm

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21 June 2018

Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Wnt signaling: a common theme in animal development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

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Regulation of cone cell formation by Canoe and Ras in the developing Drosophila eye.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

PDZ domains: targeting signalling molecules to sub-membranous sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

A novel family of Ras-binding domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

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Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast

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Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

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heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo

1 reference

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Identification of AF-6 and canoe as putative targets for Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

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Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation

1 reference

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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

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The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1 reference

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Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions

1 reference

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The dishevelled protein is modified by wingless signaling in Drosophila

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

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canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila

1 reference

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AF-6/cno: neither a kinesin nor a myosin, but a bit of both.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762375

21 June 2018

Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis

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Characterization and localization of the even-skipped protein of Drosophila

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The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.

1 reference

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Distribution and function of the lethal of scute gene product during early neurogenesis in Drosophila

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The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye.

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Myogenesis: a view from Drosophila.

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Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm.

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R7 photoreceptor specification requires Notch activity.

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Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

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Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the jun N-terminal kinase pathway in Drosophila morphogenesis.

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21 January 2018

Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6.

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21 January 2018

Interaction between Wingless and Notch signaling pathways mediated by dishevelled

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21 January 2018

Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate.

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Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors.

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Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors

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Asymmetric colocalization of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarization.

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EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output.

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Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea.

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31 October 2018

The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision.

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Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors.

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Segregation of myogenic lineages in Drosophila requires numb.

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31 October 2018

MAP kinase in situ activation atlas during Drosophila embryogenesis.

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31 October 2018

Segmental patterning of heart precursors in Drosophila.

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Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17183697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17183697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras pathway signals are required for notch-mediated oncogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17183697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0000066

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

2006PLoSO...1...66C

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

ResearchGate publication ID

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