Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein (Q33307477)

25 July 2017

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein (English)

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protein-protein interaction

25 July 2017

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Stéphane Betzi

1

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Xavier Morelli

object named as

Xavier Morelli

7

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Yves Collette

object named as

Yves Collette

8

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Stefan T Arold

object named as

Stefan T Arold

4

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author name string

Audrey Restouin

2

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25 July 2017

Sandrine Opi

3

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25 July 2017

Isabelle Parrot

5

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25 July 2017

Françoise Guerlesquin

6

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25 July 2017

language of work or name

English

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publication date

27 November 2007

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Proceedings of the National Academy of Sciences of the United States of America

25 July 2017

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25 July 2017

104

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25 July 2017

49

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25 July 2017

19256-19261

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describes a project that uses

25 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2148277/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

1 reference

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Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.

21 June 2018

1 reference

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Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

21 June 2018

1 reference

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(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.

21 June 2018

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GFscore: a general nonlinear consensus scoring function for high-throughput docking

21 June 2018

1 reference

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Comparative virtual and experimental high-throughput screening for glycogen synthase kinase-3beta inhibitors

21 June 2018

1 reference

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Biology of the HIV Nef protein.

21 June 2018

1 reference

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Therapeutic targeting of interactions between Nef and host cell proteins

21 June 2018

1 reference

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

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Hide, shield and strike back: how HIV-infected cells avoid immune eradication

21 June 2018

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Consensus scoring for ligand/protein interactions

21 June 2018

1 reference

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The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

21 June 2018

1 reference

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Property distribution of drug-related chemical databases.

21 June 2018

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Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation

21 June 2018

1 reference

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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

21 June 2018

1 reference

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Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

21 June 2018

1 reference

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The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

21 June 2018

1 reference

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A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148277

21 June 2018

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Cell biology. Lessons in rational drug design for protein kinases

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

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Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein

21 January 2018

1 reference

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Acceleration of the Drug Discovery Process: A Combinatorial Approach Using NMR Spectroscopy and Virtual Screening

21 January 2018

1 reference

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Drug discovery: the leading edge

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18042718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0707130104

1 reference

25 July 2017

0 references

1 reference

25 July 2017

1 reference