Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells (Q33322525)

25 July 2017

title

Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells (English)

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25 July 2017

10

Christopher E Rudd

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25 July 2017

Helga Schneider

1

1 reference

25 July 2017

Hongyan Wang

2

1 reference

25 July 2017

Monika Raab

3

1 reference

25 July 2017

Elke Valk

4

1 reference

25 July 2017

Xin Smith

5

1 reference

25 July 2017

Matt Lovatt

6

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25 July 2017

Zhonglin Wu

7

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25 July 2017

Braudel Maqueira-Iglesias

8

1 reference

25 July 2017

Klaus Strebhardt

9

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25 July 2017

language of work or name

English

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publication date

5 March 2008

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25 July 2017

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25 July 2017

volume

3

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25 July 2017

issue

3

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25 July 2017

page(s)

e1718

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Creative Commons Attribution 4.0 International

25 July 2017

copyright license

start time

5 March 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.

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Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion

21 June 2018

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Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.

21 June 2018

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The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1

21 June 2018

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SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

21 June 2018

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Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein

21 June 2018

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An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R

21 June 2018

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A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells

21 June 2018

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ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation

21 June 2018

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Imaging immune cell interactions and functions: SMACs and the Immunological Synapse

21 June 2018

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RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis

21 June 2018

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Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

21 June 2018

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Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

21 June 2018

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Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

21 June 2018

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Exchange factors of the RasGRP family mediate Ras activation in the Golgi

21 June 2018

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SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

21 June 2018

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Ras pathway signaling on endomembranes

21 June 2018

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Adaptors as central mediators of signal transduction in immune cells

21 June 2018

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21 June 2018

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RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

21 June 2018

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SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

21 June 2018

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Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

21 June 2018

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

21 June 2018

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SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

21 June 2018

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RasGRP links T-cell receptor signaling to Ras

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

Adaptors and molecular scaffolds in immune cell signaling

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy

21 June 2018

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VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by a mechanism involving mitogen-activated protein kinase.

21 June 2018

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Mitogen-activated protein kinase cascades and regulation of gene expression

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.

21 June 2018

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Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001718

Ras signalling on the endoplasmic reticulum and the Golgi

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

Costimulation: building an immunological synapse

31 October 2018

2 references

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001718

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2249700

Stimulation of p21 ras upon T-cell activation

31 October 2018

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Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001718

Blocked Ras activation in anergic CD4+ T cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18320039

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18320039

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0001718

1 reference

25 July 2017

0 references

1 reference

25 July 2017

1 reference