SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond (Q28298645)

Nature Reviews Immunology

Europe PubMed Central

title

SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond (English)

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author name string

Gary A Koretzky

series ordinal

1

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Farhad Abtahian

series ordinal

2

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Michael A Silverman

series ordinal

3

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language of work or name

English

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publication date

January 2006

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published in

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volume

6

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issue

1

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page(s)

67-78

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cites work

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1 reference

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

21 January 2018

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How receptor tyrosine kinases activate Ras.

21 January 2018

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

21 January 2018

1 reference

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

21 January 2018

1 reference

BLNK: a central linker protein in B cell activation

21 January 2018

1 reference

SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

21 January 2018

1 reference

Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III

21 January 2018

1 reference

The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

21 January 2018

1 reference

Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

21 January 2018

1 reference

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

1 reference

Adaptors as central mediators of signal transduction in immune cells

21 January 2018

1 reference

Jurkat T cells and development of the T-cell receptor signalling paradigm

21 January 2018

1 reference

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

21 January 2018

1 reference

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

1 reference

Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2

21 January 2018

1 reference

Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase

21 January 2018

1 reference

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

21 January 2018

1 reference

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

21 January 2018

1 reference

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

21 January 2018

1 reference

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

21 January 2018

1 reference

Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

21 January 2018

1 reference

Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 January 2018

1 reference

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 January 2018

1 reference

Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition

21 January 2018

1 reference

Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

21 January 2018

1 reference

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

21 January 2018

1 reference

Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

21 January 2018

1 reference

Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes

21 January 2018

1 reference

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

21 January 2018

1 reference

TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain.

21 January 2018

1 reference

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 January 2018

1 reference

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

1 reference

Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

21 January 2018

1 reference

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

21 January 2018

1 reference

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

21 January 2018

1 reference

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

21 January 2018

1 reference

Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

21 January 2018

1 reference

SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

21 January 2018

1 reference

A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.

21 January 2018

1 reference

Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.

21 January 2018

1 reference

A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling

21 January 2018

1 reference

Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.

21 January 2018

1 reference

T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.

21 January 2018

1 reference

BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking

21 January 2018

1 reference

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

21 January 2018

1 reference

Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling

21 January 2018

1 reference

Requirement for B cell linker protein (BLNK) in B cell development

21 January 2018

1 reference

The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes

21 January 2018

1 reference

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

21 January 2018

1 reference

The SLP-76 family of adapter proteins

21 January 2018

1 reference

Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.

21 January 2018

1 reference

Lipid rafts and signal transduction

21 January 2018

1 reference

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

21 January 2018

1 reference

Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling

21 January 2018

1 reference

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

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Functional complementation of BLNK by SLP-76 and LAT linker proteins

21 January 2018

1 reference

Lipid rafts and B-cell activation

21 January 2018

1 reference

Location is everything: lipid rafts and immune cell signaling.

21 January 2018

1 reference

LAB: a new membrane-associated adaptor molecule in B cell activation

21 January 2018

1 reference

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling

21 January 2018

1 reference

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function

21 January 2018

1 reference

Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane

21 January 2018

1 reference

Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha

21 January 2018

1 reference

The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

21 January 2018

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A leucine zipper in the N terminus confers membrane association to SLP-65

21 January 2018

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Lipid rafts: elusive or illusive?

21 January 2018

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Detergent-resistant membranes should not be identified with membrane rafts.

21 January 2018

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Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

21 January 2018

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BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

21 January 2018

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Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences

21 January 2018

1 reference

Searching for specificity in SH domains

21 January 2018

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The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.

21 January 2018

1 reference

SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils

21 January 2018

1 reference

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

21 January 2018

1 reference

Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2.

21 January 2018

1 reference

Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling

21 January 2018

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Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

21 January 2018

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Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

1 reference

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein

21 January 2018

1 reference

Differential role of SLP-76 domains in T cell development and function

21 January 2018

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Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection

21 January 2018

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SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells

21 January 2018

1 reference

Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells

21 January 2018

1 reference

Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function

21 January 2018

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Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.

21 January 2018

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Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets

21 January 2018

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Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors

21 January 2018

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21 January 2018

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Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

21 January 2018

1 reference

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

21 January 2018

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Syk tyrosine kinase required for mouse viability and B-cell development

21 January 2018

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Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

21 January 2018

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Essential role of LAT in T cell development

21 January 2018

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The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

21 January 2018

1 reference

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

21 January 2018

1 reference

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

21 January 2018

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An essential role for BLNK in human B cell development

21 January 2018

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Defects in early B-cell development: comparing the consequences of abnormalities in pre-BCR signaling in the human and the mouse

21 January 2018

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The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

21 January 2018

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Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia

21 January 2018

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Expression of the adaptor protein BLNK/SLP-65 in childhood acute lymphoblastic leukemia.

21 January 2018

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B cell defects in SLP65/BLNK-deficient mice can be partially corrected by the absence of CD22, an inhibitory coreceptor for BCR signaling

21 January 2018

1 reference

SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-induced c-Jun N-terminal kinase activation

21 January 2018

1 reference

The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation

21 January 2018

1 reference

Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP

21 January 2018

1 reference

Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice

21 January 2018

1 reference

LAT links the pre-BCR to calcium signaling

21 January 2018

1 reference

Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK

31 March 2020

1 reference

Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development

31 March 2020

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Differential requirement for SLP-76 domains in T cell development and function

31 March 2020

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Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

31 March 2020

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Tyrosine kinases in neutrophils

31 March 2020

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In vitro and in vivo macrophage function can occur independently of SLP-76

31 March 2020

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Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

31 March 2020

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B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

31 March 2020

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Cutting edge: B cell linker protein is dispensable for the allelic exclusion of immunoglobulin heavy chain locus but required for the persistence of CD5+ B cells

31 March 2020

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