Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease (Q33327216)

25 July 2017

title

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease (English)

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25 July 2017

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9

Christopher A Ross

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25 July 2017

Naoki Masuda

1

1 reference

25 July 2017

Qi Peng

2

1 reference

25 July 2017

Qing Li

3

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25 July 2017

Mali Jiang

4

1 reference

25 July 2017

Yideng Liang

5

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25 July 2017

Xiaofang Wang

6

1 reference

25 July 2017

Ming Zhao

7

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25 July 2017

Wenfei Wang

8

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25 July 2017

Wenzhen Duan

10

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25 July 2017

publication date

10 March 2008

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25 July 2017

published in

Neurobiology of Disease

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25 July 2017

volume

30

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25 July 2017

issue

3

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25 July 2017

page(s)

293-302

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Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

25 July 2017

cites work

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21 June 2018

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Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model

21 June 2018

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Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction.

21 June 2018

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Translating therapies for Huntington's disease from genetic animal models to clinical trials

21 June 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 June 2018

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Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

21 June 2018

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Protein aggregation and neurodegenerative disease

21 June 2018

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A cell-based screen for drugs to treat Huntington's disease

21 June 2018

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Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease.

21 June 2018

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Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate

21 June 2018

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Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

21 June 2018

1 reference

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Pharmacology and clinical experience with tiagabine

21 June 2018

1 reference

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Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

21 June 2018

1 reference

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The GABA transporter and its inhibitors

21 June 2018

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GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects

21 June 2018

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Recent advances on the pathogenesis of Huntington's disease

21 June 2018

1 reference

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Tiagabine: a novel antiepileptic drug

21 June 2018

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21 June 2018

1 reference

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 June 2018

1 reference

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Selective neurodegeneration in Huntington's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2468217

Differential loss of striatal projection neurons in Huntington disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2468217

Heterogeneous dopamine receptor changes in early and late Huntington's disease

21 June 2018

1 reference

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Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease

21 June 2018

1 reference

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Specific method for determination of gefitinib in human plasma, mouse plasma and tissues using high performance liquid chromatography coupled to tandem mass spectrometry

21 June 2018

1 reference

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Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2468217

Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2468217

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2468217

Pharmacokinetics of tiagabine, a gamma-aminobutyric acid-uptake inhibitor, in healthy subjects after single and multiple doses

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18395459

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NBD.2008.01.014

1 reference

release_gvu3e7aacvgs5jpie5t7slyizu

25 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gvu3e7aacvgs5jpie5t7slyizu

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

2468217

1 reference

25 July 2017

1 reference