Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle (Q33337367)

25 July 2017

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title

Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle (English)

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25 July 2017

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1

Vladimir N Uversky

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25 July 2017

Anthony L Fink

2

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PubMed ID

12095610

25 July 2017

language of work or name

English

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publication date

1 July 2002

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25 July 2017

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25 July 2017

522

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25 July 2017

1-3

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25 July 2017

9-13

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Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

25 July 2017

1 reference

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Alpha-synuclein and Parkinson's disease

7 January 2021

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Alpha-synuclein in Lewy bodies

7 January 2021

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

7 January 2021

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

7 January 2021

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

7 January 2021

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

7 January 2021

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A Drosophila model of Parkinson's disease

7 January 2021

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Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

7 January 2021

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alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

7 January 2021

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

7 January 2021

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

7 January 2021

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Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

7 January 2021

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Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

7 January 2021

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The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

7 January 2021

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

7 January 2021

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The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

7 January 2021

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Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

7 January 2021

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Amphipathic helix motif: classes and properties

7 January 2021

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Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

7 January 2021

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

7 January 2021

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Conformational properties of alpha-synuclein in its free and lipid-associated states

7 January 2021

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Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic

7 January 2021

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Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils.

7 January 2021

1 reference

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Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

7 January 2021

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beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

7 January 2021

1 reference

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

7 January 2021

1 reference

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Review: formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins

7 January 2021

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The N-terminal region of non-A beta component of Alzheimer's disease amyloid is responsible for its tendency to assume beta-sheet and aggregate to form fibrils

7 January 2021

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Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity

7 January 2021

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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

7 January 2021

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Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein OsmB

7 January 2021

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A simple method for displaying the hydropathic character of a protein

7 January 2021

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Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

7 January 2021

1 reference

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

7 January 2021

1 reference

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

7 January 2021

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Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

7 January 2021

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Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein

7 January 2021

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Nativelike secondary structure in interleukin-1 beta inclusion bodies by attenuated total reflectance FTIR.

7 January 2021

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Association of partially-folded intermediates of staphylococcal nuclease induces structure and stability

7 January 2021

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Aggregation of chymotrypsinogen: portrait by infrared spectroscopy

7 January 2021

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Secondary structure characterization of beta-lactamase inclusion bodies.

7 January 2021

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Aggregation of recombinant human interferon gamma: kinetics and structural transitions

7 January 2021

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Protein aggregation: folding aggregates, inclusion bodies and amyloid

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Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy

7 January 2021

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Effect of association state and conformational stability on the kinetics of immunoglobulin light chain amyloid fibril formation at physiological pH.

7 January 2021

1 reference

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Elucidation of the molecular mechanism during the early events in immunoglobulin light chain amyloid fibrillation. Evidence for an off-pathway oligomer at acidic pH.

7 January 2021

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Neuropathology of Parkinson's disease

7 January 2021

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7 January 2021

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Identifiers

DOI

10.1016/S0014-5793(02)02883-1

1 reference

25 July 2017

1 reference

PubMed ID

12095610