Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2 (Q33338181)

25 July 2017

title

Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2 (English)

1 reference

25 July 2017

Khatuna Gagnidze

1

1 reference

25 July 2017

Sachchidanand

2

1 reference

25 July 2017

Raphael Rozenfeld

3

1 reference

25 July 2017

Mihaly Mezei

4

1 reference

25 July 2017

Ming-Ming Zhou

5

1 reference

25 July 2017

Lakshmi A Devi

6

1 reference

25 July 2017

language of work or name

English

0 references

publication date

29 May 2008

1 reference

Journal of Medicinal Chemistry

25 July 2017

published in

1 reference

25 July 2017

volume

51

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25 July 2017

issue

12

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25 July 2017

page(s)

3378-3387

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Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseases

25 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

21 June 2018

1 reference

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Evidence that Asn542 of neprilysin (EC 3.4.24.11) is involved in binding of the P2' residue of substrates and inhibitors

21 June 2018

1 reference

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A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity

21 June 2018

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Post-translational proteolysis in polypeptide hormone biosynthesis

21 June 2018

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Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphine

21 June 2018

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Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site

21 June 2018

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Evidence that both arginine 102 and arginine 747 are involved in substrate binding to neutral endopeptidase (EC 3.4.24.11).

21 June 2018

1 reference

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Stereochemical quality of protein structure coordinates

21 June 2018

1 reference

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A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706147

Molecular modelling and site-directed mutagenesis of the active site of endothelin-converting enzyme.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706147

Molecular modeling of the active site of endothelin-converting enzyme.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706147

Enkephalinase from rat kidney. Purification, characterization, and study of substrate specificity.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706147

Novel selective quinazoline inhibitors of endothelin converting enzyme-1

31 October 2018

1 reference

12 December 2020

A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11)

1 reference

12 December 2020

Exploration of the catalytic site of endopeptidase 24.11 by site-directed mutagenesis. Histidine residues 583 and 587 are essential for catalysis

1 reference

12 December 2020

Use of site-directed mutagenesis to identify valine-573 in the S'1 binding site of rat neutral endopeptidase 24.11 (enkephalinase)

1 reference

12 December 2020

Analysis of the importance of arginine 102 in neutral endopeptidase (enkephalinase) catalysis

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM7015478

1 reference

release_enax2yjzpnfezhsctbwkot44qy

25 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/enax2yjzpnfezhsctbwkot44qy

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2706147

1 reference

25 July 2017

1 reference