Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets (Q33397149)

26 July 2017

title

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets (English)

1 reference

26 July 2017

1 reference

Michael J White

7

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Kylie D. Mason

Kylie D Mason

12

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Sarah Ellis

Sarah Ellis

10

0 references

Kelly L. Rogers

Kelly L Rogers

5

0 references

Andrew W. Roberts

Andrew W Roberts

14

0 references

Benjamin T. Kile

Benjamin T Kile

17

0 references

Emma C Josefsson

Emma C Josefsson

1

0 references

Donald Metcalf

15

Donald Metcalf

1 reference

26 July 2017

Chloé James

2

1 reference

26 July 2017

Katya J Henley

3

1 reference

26 July 2017

Marlyse A Debrincat

4

1 reference

26 July 2017

Mark R Dowling

6

1 reference

26 July 2017

Elizabeth A Kruse

8

1 reference

26 July 2017

Rachael M Lane

9

1 reference

26 July 2017

Paquita Nurden

11

1 reference

26 July 2017

Lorraine A O'Reilly

13

1 reference

26 July 2017

David C S Huang

16

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26 July 2017

language of work or name

English

0 references

publication date

12 September 2011

1 reference

Journal of Experimental Medicine

26 July 2017

published in

1 reference

26 July 2017

volume

208

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26 July 2017

issue

10

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26 July 2017

page(s)

2017-2031

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Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

26 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor

21 June 2018

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Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

21 June 2018

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Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL.

21 June 2018

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Programmed anuclear cell death delimits platelet life span.

21 June 2018

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 June 2018

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Caspases at the crossroads of immune-cell life and death

21 June 2018

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Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis

21 June 2018

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The biogenesis of platelets from megakaryocyte proplatelets

21 June 2018

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Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease

21 June 2018

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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PLATELET SEQUESTRATION IN MAN. I. METHODS.

21 June 2018

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Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura

21 June 2018

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Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro

21 June 2018

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Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death

21 June 2018

1 reference

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BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation

21 June 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 June 2018

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Antiapoptotic protein Bcl-x(L) is up-regulated during megakaryocytic differentiation of CD34(+) progenitors but is absent from senescent megakaryocytes.

21 June 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 June 2018

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 June 2018

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Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

21 June 2018

1 reference

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Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

21 June 2018

1 reference

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Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182050

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 June 2018

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Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2.

21 June 2018

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bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation

21 June 2018

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Approaches to managing carboplatin-induced thrombocytopenia: focus on the role of amifostine.

21 June 2018

1 reference

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Whole blood analysis of reticulated platelets: improvements of detection and assay stability.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182050

Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182050

Thrombopoietin signal transduction in purified murine megakaryocytes

21 June 2018

1 reference

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

21 June 2018

1 reference

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 June 2018

1 reference

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Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

21 June 2018

1 reference

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Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182050

Impaired survival of bone marrow GPIIb/IIa+ megakaryocytic cells as an additional pathogenetic mechanism of HIV-1-related thrombocytopenia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182050

P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme

21 June 2018

1 reference

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Immunohistochemical analysis of in vivo patterns of Bcl-X expression

21 June 2018

1 reference

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Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182050

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 June 2018

1 reference

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DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182050

Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182050

Structural changes in the megakaryocytes of patients infected with the human immune deficiency virus (HIV-1).

21 June 2018

1 reference

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Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties

21 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110750

Platelet formation is the consequence of caspase activation within megakaryocytes

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20110750

Platelet senescence is regulated by an internal timer, not damage inflicted by hits

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20110750

The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110750

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20110750

Observation of Antigen-Dependent CD8+ T-Cell/ Dendritic Cell Interactions in Vivo

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20110750

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20110750

Re-examining the role of cytochrome c in cell death

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20110750

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

21 January 2018

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Biotinylated platelets: a new approach to the measurement of platelet life span

21 January 2018

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12 December 2020

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

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12 December 2020

Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival

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12 December 2020

Effects of cytokines on platelet production from blood and marrow CD34+ cells

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12 December 2020

Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocytic lineage cells

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12 December 2020

Broad-spectrum caspase inhibitors: from myth to reality?

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12 December 2020

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

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12 December 2020

Identifiers

DOI

10.1084/JEM.20110750

1 reference

26 July 2017

1 reference

26 July 2017

1 reference