Genetic mechanisms in Apc-mediated mammary tumorigenesis (Q33406237)

26 July 2017

title

Genetic mechanisms in Apc-mediated mammary tumorigenesis (English)

1 reference

26 July 2017

Dmitriy Sonkin

3

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author name string

Mari Kuraguchi

1

1 reference

26 July 2017

Nana Yaw Ohene-Baah

2

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26 July 2017

Roderick Terry Bronson

4

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26 July 2017

Raju Kucherlapati

5

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26 July 2017

publication date

6 February 2009

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26 July 2017

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26 July 2017

volume

5

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26 July 2017

issue

2

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26 July 2017

page(s)

e1000367

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Creative Commons Attribution 4.0 International

26 July 2017

copyright license

start time

6 February 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesis

21 June 2018

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21 June 2018

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21 June 2018

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Purification and unique properties of mammary epithelial stem cells

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Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype

21 June 2018

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21 June 2018

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Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors

21 June 2018

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A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells

21 June 2018

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Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

21 June 2018

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Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.

21 June 2018

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The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis

21 June 2018

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Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers

21 June 2018

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Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland

21 June 2018

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Mouse models for breast cancer

21 June 2018

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

21 June 2018

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Somatic mutations of the APC gene in primary breast cancers

21 June 2018

1 reference

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Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

21 June 2018

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 June 2018

1 reference

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

21 June 2018

1 reference

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Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629572

Cre-mediated gene deletion in the mammary gland

21 June 2018

1 reference

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Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629572

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias

21 June 2018

1 reference

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Association of the APC tumor suppressor protein with catenins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629572

Association of the APC gene product with beta-catenin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629572

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629572

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629572

Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000367

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000367

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000367

Wnt-1 is dominant over neu in specifying mammary tumor expression profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000367

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000367

Folate receptor overexpression is associated with poor outcome in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000367

Epigenetic and genetic alterations ofAPCandCDH1genes in lobular breast cancer: Relationships with abnormal E-cadherin and catenin expression and microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000367

Mutations in Apc and p53 synergize to promote mammary neoplasia.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629572

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629572

Breast-Cancer Stromal Cells withTP53Mutations and Nodal Metastases

31 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000367

Loss of Apc+ in intestinal adenomas from Min mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19197353

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19197353

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19197353

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1000367

1 reference

26 July 2017

1 reference

26 July 2017

1 reference