Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships (Q33418462)

26 July 2017

Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships (English)

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26 July 2017

multiple drug resistance

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Brendan A Burkett

6

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Kin-Fai Chan

object named as

Kin-Fai Chan

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author name string

Yunzhe Zhao

2

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26 July 2017

Toby W S Chow

3

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26 July 2017

Clare S W Yan

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26 July 2017

Dik Lung Ma

5

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26 July 2017

Iris L K Wong

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26 July 2017

Larry M C Chow

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26 July 2017

Tak Hang Chan

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26 July 2017

1 April 2009

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26 July 2017

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26 July 2017

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26 July 2017

4

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26 July 2017

594-614

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Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma

26 July 2017

1 reference

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Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line

21 January 2018

1 reference

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MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

P-glycoprotein--a mediator of multidrug resistance in tumour cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Targeting multidrug resistance in cancer

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7 January 2021

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Structure of a bacterial multidrug ABC transporter

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Structural and functional asymmetry of the nucleotide-binding domains of P-glycoprotein investigated by attenuated total reflection Fourier transform infrared spectroscopy

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https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein

1 reference

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7 January 2021

Correlation between potency of calmodulin inhibitors and effects on cellular levels and cytotoxic activity of doxorubicin (adriamycin) in resistant P388 mouse leukemia cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Sufficient levels of quinine in the serum circumvent the multidrug resistance of the human leukemic cell line K562/ADM.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells.

1 reference

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7 January 2021

Reversal of multidrug resistance by B859-35, a metabolite of B859-35, niguldipine, verapamil and nitrendipine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin A

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

MDR expression in normal tissues. Pharmacologic implications for the clinical use of P-glycoprotein inhibitors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Effects of natural flavones and flavonols on the kinase activity of Cdk5.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Crystal structure of the Src family tyrosine kinase Hck

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Pig heart mitochondrial ATPase : properties of purified and membrane-bound enzyme. Effects of flavonoids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Effects of synthetic and naturally occurring flavonoids on Na+,K+-ATPase: aspects of the structure-activity relationship and action mechanism

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Effect of myricetin and other flavonoids on the liver plasma membrane Ca2+ pump. Kinetics and structure-function relationships

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Inhibition of gastric H+, K(+)-ATPase by flavonoids: a structure-activity study

1 reference

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7 January 2021

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer ce

1 reference

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7 January 2021

Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Design of Bifunctional Antibiotics that Target Bacterial rRNA and Inhibit Resistance-Causing Enzymes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

A trivalent system from vancomycin.D-ala-D-Ala with higher affinity than avidin.biotin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Bivalent probes of the human multidrug transporter P-glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800413

7 January 2021

Identifiers

DOI

10.1002/CMDC.200800413

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26 July 2017

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