Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site (Q34018799)

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English	Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site	scientific article

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scholarly article

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8 December 2019

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site (English)

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8 December 2019

multiple drug resistance

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inferred from title

1

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8 December 2019

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David M Clarke

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8 December 2019

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12 March 2002

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8 December 2019

Proceedings of the National Academy of Sciences of the United States of America

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8 December 2019

99

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8 December 2019

6

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8 December 2019

3511-3516

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8 December 2019

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

1 reference

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5 July 2018

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

1 reference

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5 July 2018

Functionally similar vanadate-induced 8-azidoadenosine 5'-[alpha-(32)P]Diphosphate-trapped transition state intermediates of human P-glycoprotin are generated in the absence and presence of ATP hydrolysis

1 reference

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5 July 2018

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

1 reference

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5 July 2018

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

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P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

1 reference

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5 July 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

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1 reference

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Multidrug resistance in oncology: diagnostic and therapeutic approaches.

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein

1 reference

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5 July 2018

Interacting helical faces of subunits a and c in the F1Fo ATP synthase of Escherichia coli defined by disulfide cross-linking

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

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5 July 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

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5 July 2018

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

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5 July 2018

The minimum functional unit of human P-glycoprotein appears to be a monomer.

1 reference

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5 July 2018

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

1 reference

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5 July 2018

The catalytic cycle of P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122554

5 July 2018

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1 reference

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Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein

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5 July 2018

Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

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5 July 2018

Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122554

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

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5 July 2018

P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

1 reference

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1 reference

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

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5 July 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

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5 July 2018

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1 reference

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Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

1 reference

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1 reference

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DNA sequencing with chain-terminating inhibitors

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1 reference

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1 reference

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21 January 2018

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1 reference

https://api.crossref.org/works/10.1073%2FPNAS.022049799

21 January 2018

Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.022049799

21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.022049799

21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

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21 January 2018

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1 reference

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Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

1 reference

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1 reference

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12 December 2020

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/11891276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/11891276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myosin active-site trapping with vanadate ion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11891276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Covalent inhibitors of P-glycoprotein ATPase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11891276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11891276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Communication between multiple drug binding sites on P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11891276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.022049799

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11891276%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

2002PNAS...99.3511L

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24 November 2022

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PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11891276%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11891276%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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