Bioactivity-guided mapping and navigation of chemical space. (Q33475595)

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1 February 2020

title

Bioactivity-guided mapping and navigation of chemical space (English)

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8

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Herbert Waldmann

13

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Willem A. Van Otterlo

2

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Marta Dominguez Seoane

3

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Tudor I Oprea

9

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Luc Brunsveld

11

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Daniel Rauh

12

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7

Ansgar Schuffenhauer

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author name string

Steffen Renner

1

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Sabine Möcklinghoff

4

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Bettina Hofmann

5

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Stefan Wetzel

6

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Dieter Steinhilber

10

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publication date

28 June 2009

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published in

Nature Chemical Biology

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volume

5

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issue

8

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page(s)

585-592

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https://scigraph.springernature.com/pub.10.1038/nchembio.188

1 February 2020

exact match

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cites work

Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.188

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

12 December 2020

The shape of things to come: structural and synthetic studies of taxol and related compounds

1 reference

12 December 2020

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

1 reference

12 December 2020

Ligand efficiency: a useful metric for lead selection

1 reference

12 December 2020

Can we rationally design promiscuous drugs?

1 reference

12 December 2020

Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases.

1 reference

12 December 2020

Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.

1 reference

12 December 2020

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

1 reference

12 December 2020

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

1 reference

12 December 2020

Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists

1 reference

12 December 2020

Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling

1 reference

12 December 2020

Virtual and biomolecular screening converge on a selective agonist for GPR30.

1 reference

12 December 2020

Chemistry and biology of the aeruginosin family of serine protease inhibitors

1 reference

12 December 2020

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

1 reference

12 December 2020

The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification.

1 reference

12 December 2020

Detection and assignment of common scaffolds in project databases of lead molecules

1 reference

12 December 2020

Clustering and Rule-Based Classifications of Chemical Structures Evaluated in the Biological Activity Space

1 reference

12 December 2020

Three-dimensional quantitative structure-activity relationship study of nonsteroidal estrogen receptor ligands using the comparative molecular field analysis/cross-validated r2-guided region selection approach.

1 reference

12 December 2020

Drugs in other drugs: a new look at drugs as fragments

1 reference

12 December 2020

Refined structure of alpha beta-tubulin at 3.5 A resolution

1 reference

12 December 2020

Biology-inspired synthesis of compound libraries

1 reference

12 December 2020

A decade of fragment-based drug design: strategic advances and lessons learned

1 reference

12 December 2020

Molecular recognition: the fragment approach in lead generation.

1 reference

12 December 2020