Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial (Q33530106)

27 July 2017

title

Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial (English)

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27 July 2017

main subject

phase I clinical trial

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13

Amagana Dolo

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Matthew Laurens

object named as

Matthew B Laurens

4

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Mahamadou A. Thera

object named as

Mahamadou A Thera

1

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Ogobara K. Doumbo

2

object named as

Ogobara K Doumbo

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Christopher V Plowe

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Issaka Sagara

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3

Drissa Coulibaly

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Mahamadou S Sissoko

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Dapa A Diallo

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Amadou Niangaly

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W Ripley Ballou

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Ally Olotu

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Kirsten E Lyke

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Marie-Claude Dubois

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D Gray Heppner

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Bourema Kouriba

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Abdoulaye K Kone

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Issa Diarra

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Lorraine Soisson

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Carter L Diggs

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Sheetij Dutta

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Modibo Daou

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Karim Traore

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Ando B Guindo

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Olivier Godeaux

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Amanda Leach

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David E Lanar

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Mounirou Baby

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Mady Sissoko

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Idrissa Traore

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Joe Cohen

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Darby Thompson

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Tina Dube

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Shannon L Takala

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Brent House

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language of work or name

English

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publication date

4 February 2010

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volume

5

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issue

2

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page(s)

e9041

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Creative Commons CC0 License

27 July 2017

copyright license

start time

4 February 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine development

1 reference

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High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model

21 June 2018

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Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming 'vaccine resistant malaria'.

21 June 2018

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A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2816207

Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2816207

Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: results of a Phase I randomized trial

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2816207

Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine design

21 June 2018

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Phase 1 study of a combination AMA1 blood stage malaria vaccine in Malian children

21 June 2018

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Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial

21 June 2018

1 reference

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Structural basis of antigenic escape of a malaria vaccine candidate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2816207

Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2816207

Safety and allele-specific immunogenicity of a malaria vaccine in Malian adults: results of a phase I randomized trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2816207

Safety and reactogenicity of an MSP-1 malaria vaccine candidate: a randomized phase Ib dose-escalation trial in Kenyan children

21 June 2018

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Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria

21 June 2018

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Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.

21 June 2018

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Population-based hematologic and immunologic reference values for a healthy Ugandan population

21 June 2018

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Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites

21 June 2018

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Impact of preseason treatment on incidence of falciparum malaria and parasite density at a site for testing malaria vaccines in Bandiagara, Mali.

21 June 2018

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In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic response

21 June 2018

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High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion

21 June 2018

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Purification, characterization, and immunogenicity of the refolded ectodomain of the Plasmodium falciparum apical membrane antigen 1 expressed in Escherichia coli

21 June 2018

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Specificity of the protective antibody response to apical membrane antigen 1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2816207

High prevalence of natural antibodies against Plasmodium falciparum 83-kilodalton apical membrane antigen (PF83/AMA-1) as detected by capture-enzyme-linked immunosorbent assay using full-length baculovirus recombinant PF83/AMA-1.

21 June 2018

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The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes

21 June 2018

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Community permission for medical research in developing countries

21 June 2018

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Incidence of severe Plasmodium falciparum malaria as a primary endpoint for vaccine efficacy trials in Bandiagara, Mali

31 October 2018

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Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum

31 October 2018

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Longitudinal study of natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in a holoendemic region of malaria in western Kenya: Asembo Bay Cohort Project VIII.

31 October 2018

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Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localization

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2816207

Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi

31 October 2018

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Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine

31 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20140214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Adjuvant activity of QS-21 isomers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20140214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0009041

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27 July 2017

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27 July 2017

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