Repositioning of an existing drug for the neglected tropical disease Onchocerciasis (Q33530297)

27 July 2017

Repositioning of an existing drug for the neglected tropical disease Onchocerciasis (English)

1 reference

27 July 2017

0 references

7

Sara Lustigman

1 reference

27 July 2017

Christian Gloeckner

1

1 reference

27 July 2017

Amanda L Garner

2

1 reference

27 July 2017

Fana Mersha

3

1 reference

27 July 2017

Yelena Oksov

4

1 reference

27 July 2017

Nancy Tricoche

5

1 reference

27 July 2017

Lisa M Eubanks

6

1 reference

27 July 2017

Gunnar F Kaufmann

8

1 reference

27 July 2017

Kim D Janda

9

1 reference

27 July 2017

language of work or name

English

0 references

publication date

8 February 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

27 July 2017

1 reference

27 July 2017

107

1 reference

27 July 2017

8

1 reference

27 July 2017

3424-3429

1 reference

Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden

27 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Chitinase is stored and secreted from the inner body of microfilariae and has a role in exsheathment in the parasitic nematode Brugia malayi

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Of mice, cattle, and humans: the immunology and treatment of river blindness

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Function-oriented synthesis, step economy, and drug design

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Ivermectin: 25 years and still going strong

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Essential role of chitinase in the development of the filarial nematode Acanthocheilonema viteae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

21 June 2018

New uses for old drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Drug discovery and development for neglected parasitic diseases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Innovative lead discovery strategies for tropical diseases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

River blindness: a success story under threat?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Natural product family 18 chitinase inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Opportunities and Challenges in Antiparasitic Drug Discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

The life and times of ivermectin - a success story

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Drug repositioning: identifying and developing new uses for existing drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Immunocompetence may be important in the effectiveness of Mectizan (ivermectin) in the treatment of human onchocerciasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Expression and secretion of a larval-specific chitinase (family 18 glycosyl hydrolase) by the infective stages of the parasitic nematode, Onchocerca volvulus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Structural insights into the catalytic mechanism of a family 18 exo-chitinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Modes of action of anthelmintic drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Chitinase genes expressed by infective larvae of the filarial nematodes, Acanthocheilonema viteae and Onchocerca volvulus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Transglutaminase-catalyzed reaction is important for molting of Onchocerca volvulus third-stage larvae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Cloning and expression of a Streptomyces plicatus chitinase (chitinase-63) in Escherichia coli.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

The effect of the hydrogen ionophore closantel upon the pharmacology and ultrastructure of the adult liver fluke Fasciola hepatica

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Onchocerca volvulus: biochemical and morphological characteristics of the surface of third- and fourth-stage larvae.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Chitin metabolism: a target for drugs against parasites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Closantel, a new antiparasitic hydrogen ionophore [proceedings]

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840490

Parasitic nematodes have two distinct chitin synthases.

21 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

Unravelling the moulting degradome: new opportunities for chemotherapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

Characterization of a novel filarial serine protease inhibitor, Ov-SPI-1, from Onchocerca volvulus, with potential multifunctional roles during development of the parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

Thirty-month follow-up of sub-optimal responders to multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

Lymphotropic antifilarial agents derived from closantel and chlorambucil.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

Pharmacokinetics of a novel closantel/ivermectin injection in cattle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0915125107

Chitin in egg shells of Onchocerca gibsoni and Onchocerca volvulus

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20142509

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0915125107

1 reference

27 July 2017

0 references

1 reference

27 July 2017

1 reference