High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding (Q33534982)

27 July 2017

title

High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding (English)

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27 July 2017

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10

Vineet Gupta

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27 July 2017

2

Dony Maiguel

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27 July 2017

1

Mohd Hafeez Faridi

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27 July 2017

5

Constantinos J Barth

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27 July 2017

Brock T Brown

3

1 reference

27 July 2017

Eigo Suyama

4

1 reference

27 July 2017

Michael Hedrick

6

1 reference

27 July 2017

Stefan Vasile

7

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27 July 2017

Eduard Sergienko

8

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27 July 2017

Stephan Schürer

9

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27 July 2017

language of work or name

English

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publication date

25 February 2010

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Biochemical and Biophysical Research Communications

27 July 2017

published in

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27 July 2017

volume

394

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27 July 2017

issue

1

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27 July 2017

page(s)

194-199

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Utilizing high throughput screening data for predictive toxicology models: protocols and application to MLSCN assays

27 July 2017

cites work

1 reference

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Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

21 June 2018

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A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18

21 June 2018

1 reference

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Targeting leukocyte integrins in human diseases

21 June 2018

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Therapeutic antagonists and conformational regulation of integrin function

21 June 2018

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Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter

21 June 2018

1 reference

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A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins

21 June 2018

1 reference

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Integrins: bidirectional, allosteric signaling machines

21 June 2018

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CD18 activation epitopes induced by leukocyte activation

21 June 2018

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Shape and shift changes related to the function of leukocyte integrins LFA-1 and Mac-1.

21 June 2018

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An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

21 June 2018

1 reference

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CD18 trials disappoint again

21 June 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 June 2018

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

21 June 2018

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Ligand binding to integrins

21 June 2018

1 reference

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Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty

21 June 2018

1 reference

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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

21 June 2018

1 reference

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Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury

21 June 2018

1 reference

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A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits

21 June 2018

1 reference

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Peptides derived from the complementarity-determining regions of anti-Mac-1 antibodies block intercellular adhesion molecule-1 interaction with Mac-1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065194

A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis

21 June 2018

1 reference

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CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus.

21 June 2018

1 reference

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Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin

21 June 2018

1 reference

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Antibodies that activate beta 2 integrins can generate different ligand binding states

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065194

Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies

21 June 2018

1 reference

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Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response

21 June 2018

1 reference

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Systematic analysis of large screening sets in drug discovery.

21 June 2018

1 reference

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Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065194

Small molecule antagonists of complement receptor type 3 block adhesion and adhesion-dependent oxidative burst in human polymorphonuclear leukocytes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065194

Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20188705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/20188705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20188705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BBRC.2010.02.151

1 reference

27 July 2017

1 reference

27 July 2017

1 reference