Endogenous oxidative damage of mtDNA. (Q33538099)

27 July 2017

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title

Endogenous oxidative damage of mtDNA. (English)

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27 July 2017

2

Ames BN

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27 July 2017

Beckman KB

1

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PubMed ID

10064849

27 July 2017

language of work or name

English

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publication date

1 March 1999

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27 July 2017

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27 July 2017

424

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27 July 2017

1-2

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27 July 2017

51-58

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DNA oxidative damage and life expectancy in houseflies

27 July 2017

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Oxidants, antioxidants, and the degenerative diseases of aging

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Mitochondrial decay in aging

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Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA.

7 January 2021

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Deleterious mitochondrial DNA mutations accumulate in aging human tissues

7 January 2021

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Detection and quantification of oxidative adducts of mitochondrial DNA.

7 January 2021

1 reference

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7 January 2021

Oxidative Decay of DNA

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Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing.

7 January 2021

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Artifacts associated with the measurement of oxidized DNA bases.

7 January 2021

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Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997

7 January 2021

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Oxidative DNA damage in human cells: the influence of antioxidants and DNA repair

7 January 2021

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Mitochondrial dysfunction in neurodegeneration

7 January 2021

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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

7 January 2021

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Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death.

7 January 2021

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Detection of a specific mitochondrial DNA deletion in tissues of older humans

7 January 2021

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A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues

7 January 2021

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An oxidative damage-specific endonuclease from rat liver mitochondria.

7 January 2021

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Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells

7 January 2021

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Detection of single-strand breaks and formamidopyrimidine-DNA glycosylase-sensitive sites in DNA of cultured human fibroblasts.

7 January 2021

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In vivo accumulation of 8-hydroxy-2'-deoxyguanosine in DNA correlates with release of reactive oxygen species in Fanconi's anaemia families

7 January 2021

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Observation and prevention of an artefactual formation of oxidized DNA bases and nucleosides in the GC-EIMS method.

7 January 2021

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Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA.

7 January 2021

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Is cell aging caused by respiration-dependent injury to the mitochondrial genome?

7 January 2021

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Hydroxyl radical generation during mitochondrial electron transfer and the formation of 8-hydroxydesoxyguanosine in mitochondrial DNA.

7 January 2021

1 reference

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Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase

7 January 2021

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Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

7 January 2021

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Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine

7 January 2021

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Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

7 January 2021

1 reference

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Quantification of oxidative DNA modifications in mitochondria.

7 January 2021

1 reference

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DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

7 January 2021

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Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide

7 January 2021

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Purification of all forms of HeLa cell mitochondrial DNA and assessment of damage to it caused by hydrogen peroxide treatment of mitochondria or cells.

7 January 2021

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Lung carcinogenesis and formation of 8-hydroxy-deoxyguanosine in mice by diesel exhaust particles

7 January 2021

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Repair of products of oxidative DNA base damage in human cells

7 January 2021

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7 January 2021

1 reference

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Mutational spectrometry without phenotypic selection: human mitochondrial DNA.

7 January 2021

1 reference

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Mitochondrial mutational spectra in human cells and tissues

7 January 2021

1 reference

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Age-associated alterations of the mitochondrial genome

7 January 2021

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Rates of mitochondrial DNA evolution in sharks are slow compared with mammals

7 January 2021

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Body size, metabolic rate, generation time, and the molecular clock

7 January 2021

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Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

7 January 2021

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Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

7 January 2021

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An update on the mitochondrial-DNA mutation hypothesis of cell aging

7 January 2021

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Mitochondrial role in cell aging

7 January 2021

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Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue

7 January 2021

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Vitamin C exhibits pro-oxidant properties.

7 January 2021

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Reactive oxygen and DNA damage in mitochondria

7 January 2021

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Oxidative damage to mitochondrial DNA and its relationship to ageing.

7 January 2021

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Normal oxidative damage to mitochondrial and nuclear DNA is extensive

7 January 2021

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Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts

7 January 2021

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Oxidative damage and mitochondrial decay in aging

7 January 2021

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Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

7 January 2021

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Oxidative DNA damage in human respiratory tract epithelial cells. Time course in relation to DNA strand breakage

7 January 2021

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Age-associated damage in mitochondrial function in rat hearts

7 January 2021

1 reference

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Mitochondrial DNA in aging and disease

7 January 2021

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Mitochondrial DNA mutations in human degenerative diseases and aging

7 January 2021

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Detection and quantification of 8-hydroxydeoxyguanosine adducts in peripheral blood of people exposed to ionizing radiation

7 January 2021

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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

7 January 2021

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Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis

7 January 2021

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Comparison of Oxidative Base Damage in Mitochondrial and Nuclear DNA

7 January 2021

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Oxidative DNA base damage and its repair in kidneys and livers of nickel(II)-treated male F344 rats.

7 January 2021

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10.1016/S0027-5107(99)00007-X

7 January 2021

Identifiers

DOI

1 reference

27 July 2017

1 reference

PubMed ID

10064849