Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction (Q33547796)

28 July 2017

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title

Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction (English)

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28 July 2017

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Edwards KM

1

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28 July 2017

Davis JE

2

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28 July 2017

Browne KA

3

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28 July 2017

Sutton VR

4

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28 July 2017

Trapani JA

5

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28 July 2017

publication date

1 February 1999

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Immunology & Cell Biology

28 July 2017

published in

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28 July 2017

volume

77

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28 July 2017

issue

1

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28 July 2017

page(s)

76-89

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Apoptosis by death factor

28 July 2017

cites work

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M-T2: a poxvirus TNF receptor homologue with dual activities.

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A 14,500 MW protein is coded by region E3 of group C human adenoviruses

21 January 2018

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Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

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21 January 2018

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21 January 2018

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Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.

21 January 2018

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Identification and preliminary characterization of a protein motif related to the zinc finger

21 January 2018

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Control of programmed cell death by the baculovirus genes p35 and iap.

21 January 2018

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cyclin encoded by KS herpesvirus

21 January 2018

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Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation

21 January 2018

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Perforin-mediated target cell lysis by cytolytic T lymphocytes

21 January 2018

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Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

21 January 2018

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A natural killer cell granule protein that induces DNA fragmentation and apoptosis

21 January 2018

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Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

21 January 2018

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21 January 2018

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21 January 2018

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Specific release of proteoglycans from human natural killer cells during target lysis.

21 January 2018

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Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes

21 January 2018

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Cloning of a gene that encodes a new member of the human cytotoxic cell protease family

21 January 2018

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Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)

21 January 2018

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Structure and evolutionary origin of the human granzyme H gene

21 January 2018

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The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments

21 January 2018

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Electron microscopic study of natural killer cell-tumor cell conjugates

21 January 2018

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Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

21 January 2018

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Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

21 January 2018

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Mechanism of lymphocyte-mediated cytotoxicity

21 January 2018

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Debate: the mechanism of lymphocyte-mediated killing. Lymphocyte-triggered internal target disintegration

21 January 2018

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21 January 2018

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

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A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

21 January 2018

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CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity.

21 January 2018

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Immune function in mice lacking the perforin gene

21 January 2018

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Decreased tumor surveillance in perforin-deficient mice

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Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo

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Purified perforin induces target cell lysis but not DNA fragmentation

21 January 2018

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Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes

21 January 2018

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Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors

21 January 2018

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Lymphocyte-Mediated Cytolysis Role of Granule Mediators

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HYPOTHESIS: CYTOTOXIC LYMPHOCYTE GRANULE SERINE PROTEASES ACTIVATE TARGET CELL ENDONUCLEASES TO TRIGGER APOPTOSIS

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The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity

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A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

21 January 2018

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Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

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21 January 2018

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Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 January 2018

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21 January 2018

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Cytotoxic T lymphocyte mediated cytolysis

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Granzymes: exogenous proteinases that induce target cell apoptosis.

21 January 2018

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Proteases and lymphocyte cytotoxic killing mechanisms

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Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

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Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

21 January 2018

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Activation of pro-urokinase by the human T cell-associated serine proteinase HuTSP-1.

21 January 2018

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Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

21 January 2018

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In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

21 January 2018

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An antimicrobial activity of cytolytic T cells mediated by granulysin

21 January 2018

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Cleavage of caspase family members by granzyme B: a comparative study in vitro.

21 January 2018

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Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

21 January 2018

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Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

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Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

21 January 2018

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10.1046/J.1440-1711.1999.00799.X

21 January 2018

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DOI

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28 July 2017

1 reference