Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model (Q33552991)

28 July 2017

Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model (English)

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28 July 2017

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ChEBI release 2020-05-28

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Hernan Lorenzi

5

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author name string

Ishita Das

1

1 reference

28 July 2017

Joo-Min Park

2

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28 July 2017

Jung H Shin

3

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28 July 2017

Soo Kyeong Jeon

4

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28 July 2017

David J Linden

6

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28 July 2017

Paul F Worley

7

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28 July 2017

Roger H Reeves

8

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28 July 2017

language of work or name

English

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publication date

1 September 2013

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Science Translational Medicine

28 July 2017

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28 July 2017

5

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28 July 2017

201

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28 July 2017

201ra120

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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Distributed synergistic plasticity and cerebellar learning

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Scrutinizing ciliopathies by unraveling ciliary interaction networks

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

The use of mouse models to understand and improve cognitive deficits in Down syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Reevaluating the role of LTD in cerebellar motor learning

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Intravenous hedgehog agonist induces proliferation of neural and oligodendrocyte precursors in rodent spinal cord injury

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

A year of unprecedented progress in Down syndrome basic research

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Chromosome 21 and down syndrome: from genomics to pathophysiology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

The neuropsychology of Down syndrome: evidence for hippocampal dysfunction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Small molecule modulation of Smoothened activity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Sonic hedgehog regulates the growth and patterning of the cerebellum

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Altered neural cell fates and medulloblastoma in mouse patched mutants

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

A mouse model for Down syndrome exhibits learning and behaviour deficits.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006719

Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse.

14 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Hippocampus-dependent learning promotes survival of new neurons in the dentate gyrus at a specific time during cell maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Regulation of hippocampal neurogenesis in adulthood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Lobule-specific membrane excitability of cerebellar Purkinje cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Motor learning in Ts65Dn mice, a model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

The cerebellum in the spatial problem solving: a co-star or a guest star?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

Role of the cerebellar cortex in conditioned goal-directed behavior.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005983

10.1126/SCITRANSLMED.3005983

21 January 2018

Identifiers

DOI

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28 July 2017

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28 July 2017

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