Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria (Q33556308)

28 July 2017

title

Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria (English)

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28 July 2017

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19 December 2018

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Blandine Franke-Fayard

4

Blandine Franke-Fayard

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Manlio Di Cristina

Manlio Di Cristina

7

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Chris J Janse

Chris J Janse

2

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Andrea Crisanti

14

Andrea Crisanti

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28 July 2017

11

Francesco Bistoni

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28 July 2017

10

Antonio Cassone

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28 July 2017

9

Andrea Savarino

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28 July 2017

Roberta Spaccapelo

1

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28 July 2017

Sara Caterbi

3

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28 July 2017

J Alfredo Bonilla

5

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28 July 2017

Luke M Syphard

6

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28 July 2017

Tania Dottorini

8

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28 July 2017

Andrew P Waters

12

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28 July 2017

John B Dame

13

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28 July 2017

language of work or name

English

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publication date

17 December 2009

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The American Journal of Pathology

28 July 2017

published in

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28 July 2017

volume

176

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28 July 2017

issue

1

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28 July 2017

page(s)

205-217

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Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity.

28 July 2017

cites work

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21 June 2018

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Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection

21 June 2018

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Chemical attenuation of Plasmodium berghei sporozoites induces sterile immunity in mice.

21 June 2018

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A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria

21 June 2018

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A case for whole-parasite malaria vaccines.

21 June 2018

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High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei

21 June 2018

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Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.

21 June 2018

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Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems

21 June 2018

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Regulating immunity to malaria

21 June 2018

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Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination

21 June 2018

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Experimental models of cerebral malaria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

High efficiency transfection of Plasmodium berghei facilitates novel selection procedures

21 June 2018

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Immunological processes in malaria pathogenesis.

21 June 2018

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Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration

21 June 2018

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Interactions between malaria parasites and the host immune system

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process

21 June 2018

1 reference

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Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

The importance of the spleen in malaria

21 June 2018

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Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

21 June 2018

1 reference

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Manipulating the Plasmodium genome.

21 June 2018

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A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Cerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans

21 June 2018

1 reference

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Plasmodium berghei: recombinant interferon-gamma and the development of parasitemia and cerebral lesions in malaria-infected mice

21 June 2018

1 reference

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Flow cytometry in malaria detection

21 June 2018

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Plasmodium berghei: isolation and maintenance of an irradiation attenuated strain in the nude mouse

21 June 2018

1 reference

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Chronic, patent Plasmodium berghei malaria in splenectomized mice

21 June 2018

1 reference

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Resolution of acute malaria (Plasmodium berghei in the rat): reversibility and spleen dependence

21 June 2018

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Mechanisms of splenic control of murine malaria: cellular reactions of the spleen in lethal (strain 17XL) Plasmodium yoelii malaria in BALB/c mice, and the consequences of pre-infective splenectomy.

21 June 2018

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Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Selection by flow-sorting of genetically transformed, GFP-expressing blood stages of the rodent malaria parasite, Plasmodium berghei.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Real-time in vivo imaging of transgenic bioluminescent blood stages of rodent malaria parasites in mice.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Plasmodium berghei alpha-tubulin II: a role in both male gamete formation and asexual blood stages

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

The role of Plasmodium falciparum food vacuole plasmepsins

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Plasmodium berghei: the application of cultivation and purification techniques to molecular studies of malaria parasites

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Malaria parasites lacking eef1a have a normal S/M phase yet grow more slowly due to a longer G1 phase.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

Interleukin-12-dependent mechanisms in the clearance of blood-stage murine malaria parasite Plasmodium berghei XAT, an attenuated variant of P. berghei NK65.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797883

10.2353/AJPATH.2010.090504

31 October 2018

Identifiers

DOI

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28 July 2017

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28 July 2017

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