Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection. (Q33595066)

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29 February 2020

title

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection (English)

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29 February 2020

1

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29 February 2020

Nikolaos Eleftheriadis

3

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29 February 2020

Matthew P. Baumgartner

4

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29 February 2020

Hidde J. Haisma

6

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29 February 2020

Frank J Dekker

7

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29 February 2020

author name string

Petra A M Kok

2

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29 February 2020

Carlos J Camacho

5

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29 February 2020

language of work or name

English

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publication date

23 October 2013

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Bioorganic & Medicinal Chemistry

29 February 2020

published in

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volume

21

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29 February 2020

issue

24

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29 February 2020

page(s)

7763-7778

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Lessons learned in empirical scoring with smina from the CSAR 2011 benchmarking exercise

29 February 2020

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Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model

21 June 2018

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21 June 2018

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21 June 2018

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12R-lipoxygenase deficiency disrupts epidermal barrier function

21 June 2018

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Total synthesis of cavicularin and riccardin C: addressing the synthesis of an arene that adopts a boat configuration

21 June 2018

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Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanoma progression, under experimental and clinical conditions

21 June 2018

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21 June 2018

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Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.

21 June 2018

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15-lipoxygenase: a Janus enzyme?

21 June 2018

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RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

21 June 2018

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Lipoxygenase-5 is overexpressed in prostate adenocarcinoma

21 June 2018

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Cyclooxygenases: structural, cellular, and molecular biology

21 June 2018

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Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

21 June 2018

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The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

21 June 2018

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Discovery of a second 15S-lipoxygenase in humans

21 June 2018

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Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

21 June 2018

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Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis

21 June 2018

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Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis

21 June 2018

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Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

21 June 2018

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Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea

21 June 2018

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Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells

21 June 2018

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21 June 2018

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Micelle and acid-soap formation of linoleic acid and 13-L-hydroperoxylinoleic acid being substrates of lipoxygenase-1

21 June 2018

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Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative

21 June 2018

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Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke.

30 October 2018

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Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency

30 October 2018

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Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis

30 October 2018

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Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice.

30 October 2018

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Increased expression of 5-lipoxygenase in high-grade astrocytomas

30 October 2018

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Lipoxygenase inhibitory activity of anacardic acids

30 October 2018

1 reference

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Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition

30 October 2018

1 reference

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Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer

30 October 2018

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Regulation of 15-lipoxygenase isozymes and mucin secretion by cytokines in cultured normal human bronchial epithelial cells

30 October 2018

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Assessing the performance of OMEGA with respect to retrieving bioactive conformations

30 October 2018

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12 December 2020

Steady-state kinetics of lipoxygenase oxygenation of unsaturated fatty acids

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12 December 2020

Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions

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12 December 2020

Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease

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12 December 2020

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer

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12 December 2020

Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease

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12 December 2020

Regiocontrolled intramolecular cyclizations of carboxylic acids to carbon-carbon triple bonds promoted by acid or base catalyst

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12 December 2020

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

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12 December 2020

10.1016/J.BMC.2013.10.015

Identifiers

DOI

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29 February 2020

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29 February 2020

PubMed publication ID

24231650

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