NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function. (Q33601322)

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English	NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.	scientific article

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8 March 2020

NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function (English)

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Sheryl M Gough

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Peter D Aplan

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author name string

Fan Lee

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Fan Yang

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Robert L Walker

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Yeulin J Zhu

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Marbin Pineda

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8 March 2020

Masahiro Onozawa

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Yang Jo Chung

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Sven Bilke

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Elise K Wagner

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8 March 2020

John M Denu

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8 March 2020

Yi Ning

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Bowen Xu

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8 March 2020

Paul S Meltzer

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publication date

17 February 2014

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8 March 2020

Cancer Discovery

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8 March 2020

4

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5

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8 March 2020

564-577

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8 March 2020

POU1F1 is a novel fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15).

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14 July 2018

Structure and function of the BAH domain in chromatin biology

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Chromatin modifications as therapeutic targets in MLL-rearranged leukemia

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Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma

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Depletion of cytotoxic T-cells does not protect NUP98-HOXD13 mice from myelodysplastic syndrome but reveals a modest tumor immunosurveillance effect

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Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences.

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

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NKL homeobox genes in leukemia.

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14 July 2018

Identification and characterization of Hoxa9 binding sites in hematopoietic cells

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14 July 2018

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

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14 July 2018

Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome.

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Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

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14 July 2018

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

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14 July 2018

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

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14 July 2018

Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell

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14 July 2018

MLL translocations, histone modifications and leukaemia stem-cell development

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14 July 2018

Chromatin remodeling and cancer, Part I: Covalent histone modifications

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14 July 2018

Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice

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14 July 2018

Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

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14 July 2018

Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

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14 July 2018

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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14 July 2018

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation

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14 July 2018

A stem cell molecular signature

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14 July 2018

Bethesda proposals for classification of lymphoid neoplasms in mice.

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14 July 2018

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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14 July 2018

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14 July 2018

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14 July 2018

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

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14 July 2018

Definition of acute biphenotypic leukemia.

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14 July 2018

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

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30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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1 reference

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30 October 2018

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern

1 reference

https://pubmed.ncbi.nlm.nih.gov/24535671

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment

1 reference

https://pubmed.ncbi.nlm.nih.gov/24535671

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24535671

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disulfiram blood levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/24535671

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

1 reference

https://pubmed.ncbi.nlm.nih.gov/24535671

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24535671

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24535671

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/2159-8290.CD-13-0419

1 reference

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8 March 2020

1 reference

Europe PubMed Central

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8 March 2020

1 reference

Europe PubMed Central

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8 March 2020

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