Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome (Q33601622)

28 July 2017

title

Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome (English)

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28 July 2017

Jonathan D Mosley

2

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Elaine Mardis

16

object named as

Elaine R Mardis

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28 July 2017

19

Dan M Roden

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28 July 2017

Peter Weeke

1

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28 July 2017

David Hanna

3

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28 July 2017

Jessica T Delaney

4

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28 July 2017

Christian Shaffer

5

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28 July 2017

Quinn S Wells

6

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28 July 2017

Sara Van Driest

7

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28 July 2017

Jason H Karnes

8

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28 July 2017

Christie Ingram

9

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28 July 2017

Yan Guo

10

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28 July 2017

Yu Shyr

11

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28 July 2017

Kris Norris

12

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28 July 2017

Prince J Kannankeril

13

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28 July 2017

Andrea H Ramirez

14

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28 July 2017

Joshua D Smith

15

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28 July 2017

Deborah Nickerson

17

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28 July 2017

Alfred L George

18

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28 July 2017

language of work or name

English

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publication date

19 February 2014

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Journal of the American College of Cardiology

28 July 2017

published in

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28 July 2017

volume

63

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28 July 2017

issue

14

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28 July 2017

page(s)

1430-1437

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Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome

14 July 2018

1 reference

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QT variability during initial exposure to sotalol: experience based on a large electronic medical record.

14 July 2018

1 reference

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Calmodulin mutations associated with recurrent cardiac arrest in infants

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Evolution and functional impact of rare coding variation from deep sequencing of human exomes

14 July 2018

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Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes.

14 July 2018

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Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Rare-variant association testing for sequencing data with the sequence kernel association test

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Pooled association tests for rare variants in exon-resequencing studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Systems pharmacology of arrhythmias

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

NOS1AP is a genetic modifier of the long-QT syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Common variants at ten loci influence QT interval duration in the QTGEN Study

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

SLCO1B1 variants and statin-induced myopathy--a genomewide study

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Network properties of genes harboring inherited disease mutations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Long QT syndrome: reduced repolarization reserve and the genetic link

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Drug-induced prolongation of the QT interval

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Molecular and cellular mechanisms of cardiac arrhythmias

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Acn9 is a novel protein of gluconeogenesis that is located in the mitochondrial intermembrane space

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018823

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24561134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Taking the "idio" out of "idiosyncratic": predicting torsades de pointes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24561134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24561134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.JACC.2014.01.031

1 reference

28 July 2017

1 reference

28 July 2017

1 reference