The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells (Q33612421)

28 July 2017

title

The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells (English)

1 reference

28 July 2017

main subject

hepatocellular carcinoma

1 reference

Bin Wang

1

1 reference

28 July 2017

Zhenhong Ni

2

1 reference

28 July 2017

Xufang Dai

3

1 reference

28 July 2017

Liyan Qin

4

1 reference

28 July 2017

Xinzhe Li

5

1 reference

28 July 2017

Liang Xu

6

1 reference

28 July 2017

Jiqin Lian

7

1 reference

28 July 2017

Fengtian He

8

1 reference

28 July 2017

publication date

30 April 2014

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28 July 2017

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28 July 2017

volume

13

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28 July 2017

page(s)

98

1 reference

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells

28 July 2017

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Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

21 June 2018

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Mcl-1; the molecular regulation of protein function

21 June 2018

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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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mTORC1 promotes survival through translational control of Mcl-1.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

21 June 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 June 2018

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21 June 2018

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

21 June 2018

1 reference

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Bcl-2 and Bcl-xL are important for the induction of paclitaxel resistance in human hepatocellular carcinoma cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021276

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021276

Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1476-4598-13-98

Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC).

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1476-4598-13-98

Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells

21 January 2018

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Crossref

https://api.crossref.org/works/10.1186%2F1476-4598-13-98

BH3 mimetics reduce adhesion and migration of hepatoblastoma and hepatocellular carcinoma cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24779770

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1476-4598-13-98

1 reference

Dimensions Publication ID

28 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1476-4598-13-98

9 September 2019

1 reference

28 July 2017

1 reference